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CHST2

GENERAL INFORMATION

Gene name

 CHST2

Gene description

 Carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2

Protein class

 Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (ASC TERT1, HEL, HMC-1, U-266/70, WM-115)
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 CHST2 (HGNC Symbol)

Synonyms

 C6ST

Description

 Carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2 (HGNC Symbol)

Entrez gene summary

 This locus encodes a sulfotransferase protein. The encoded enzyme catalyzes the sulfation of a nonreducing N-acetylglucosamine residue, and may play a role in biosynthesis of 6-sulfosialyl Lewis X antigen. [provided by RefSeq, Aug 2011]

Chromosome

 3

Cytoband

 q24

Chromosome location (bp)

 143119331 - 143124014

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000175040 (version 83.38)

Entrez gene

 9435

UniProt

 Q9Y4C5 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9Y4C5

Antibodypedia

 CHST2 antibodies

PROTEIN BROWSER
CHST2-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CHST2-001
ENSP00000307911
ENST00000309575
Q9Y4C5 [Direct mapping]
Carbohydrate sulfotransferase 2
V9HVX9 [Target identity:100%; Query identity:100%]
Sulfotransferase
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
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GO:0000139 [Golgi membrane]
GO:0001517 [N-acetylglucosamine 6-O-sulfotransferase activity]
GO:0005802 [trans-Golgi network]
GO:0005975 [carbohydrate metabolic process]
GO:0006044 [N-acetylglucosamine metabolic process]
GO:0006790 [sulfur compound metabolic process]
GO:0006954 [inflammatory response]
GO:0007275 [multicellular organismal development]
GO:0008146 [sulfotransferase activity]
GO:0016021 [integral component of membrane]
GO:0018146 [keratan sulfate biosynthetic process]
GO:0030203 [glycosaminoglycan metabolic process]
GO:0031228 [intrinsic component of Golgi membrane]
GO:0042339 [keratan sulfate metabolic process]
GO:0044281 [small molecule metabolic process]
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 530 aa
57.9 kDa 		No 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.