Fields »
ABOUT
HELP
BLOG
UBE2C

GENERAL INFORMATION

Gene name

 UBE2C

Gene description

 Ubiquitin-conjugating enzyme E2C

Protein class

 Cancer-related genes
Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 7
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Mixed
GTEx:Tissue enhanced (esophagus)
FANTOM5:Tissue enhanced (appendix, tonsil)

Protein evidence

 Evidence at protein level

Protein expression

 General cytoplasmic expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 3 antibodies.
HPA054975 , CAB011464 , CAB035990
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Tonsil

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (esophagus)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (appendix, tonsil)

GENE INFORMATION

Gene name

 UBE2C (HGNC Symbol)

Synonyms

 UBCH10

Description

 Ubiquitin-conjugating enzyme E2C (HGNC Symbol)

Entrez gene summary

 The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, ubiquitin-conjugating enzymes, and ubiquitin-protein ligases. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein is required for the destruction of mitotic cyclins and for cell cycle progression, and may be involved in cancer progression. Multiple transcript variants encoding different isoforms have been found for this gene. Pseudogenes of this gene have been defined on chromosomes 4, 14, 15, 18, and 19. [provided by RefSeq, Aug 2013]

Chromosome

 20

Cytoband

 q13.12

Chromosome location (bp)

 45812576 - 45816957

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000175063 (version 83.38)

Entrez gene

 11065

UniProt

 O00762 (UniProt - Evidence at protein level)

neXtProt

 NX_O00762

Antibodypedia

 UBE2C antibodies

PROTEIN BROWSER
UBE2C-001
UBE2C-003
UBE2C-004
UBE2C-005
UBE2C-006
UBE2C-201
UBE2C-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
UBE2C-001
ENSP00000348838
ENST00000356455
O00762 [Direct mapping]
Ubiquitin-conjugating enzyme E2 C
Q5TZN3 [Target identity:100%; Query identity:100%]
UBE2C protein; Ubiquitin-conjugating enzyme E2C; Ubiquitin-conjugating enzyme E2C, isoform CRA_e
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005680 [anaphase-promoting complex]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0007094 [mitotic spindle assembly checkpoint]
GO:0008054 [negative regulation of cyclin-dependent protein serine/threonine kinase by cyclin degradation]
GO:0010458 [exit from mitosis]
GO:0010994 [free ubiquitin chain polymerization]
GO:0016567 [protein ubiquitination]
GO:0030071 [regulation of mitotic metaphase/anaphase transition]
GO:0031145 [anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process]
GO:0031536 [positive regulation of exit from mitosis]
GO:0031625 [ubiquitin protein ligase binding]
GO:0051301 [cell division]
GO:0051436 [negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle]
GO:0051437 [positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition]
GO:0051439 [regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle]
GO:0051488 [activation of anaphase-promoting complex activity]
GO:0061630 [ubiquitin protein ligase activity]
GO:0061631 [ubiquitin conjugating enzyme activity]
GO:0070936 [protein K48-linked ubiquitination]
GO:0070979 [protein K11-linked ubiquitination]
Show all
 179 aa
19.7 kDa 		No 0
UBE2C-003
ENSP00000335674
ENST00000335046
O00762 [Direct mapping]
Ubiquitin-conjugating enzyme E2 C
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005680 [anaphase-promoting complex]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0007094 [mitotic spindle assembly checkpoint]
GO:0008054 [negative regulation of cyclin-dependent protein serine/threonine kinase by cyclin degradation]
GO:0010458 [exit from mitosis]
GO:0010994 [free ubiquitin chain polymerization]
GO:0016567 [protein ubiquitination]
GO:0030071 [regulation of mitotic metaphase/anaphase transition]
GO:0031145 [anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process]
GO:0031536 [positive regulation of exit from mitosis]
GO:0031625 [ubiquitin protein ligase binding]
GO:0051301 [cell division]
GO:0051436 [negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle]
GO:0051437 [positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition]
GO:0051439 [regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle]
GO:0051488 [activation of anaphase-promoting complex activity]
GO:0061630 [ubiquitin protein ligase activity]
GO:0061631 [ubiquitin conjugating enzyme activity]
GO:0070936 [protein K48-linked ubiquitination]
GO:0070979 [protein K11-linked ubiquitination]
Show all
 161 aa
17.4 kDa 		No 0
UBE2C-004
ENSP00000361649
ENST00000372568
O00762 [Direct mapping]
Ubiquitin-conjugating enzyme E2 C
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005680 [anaphase-promoting complex]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0007094 [mitotic spindle assembly checkpoint]
GO:0008054 [negative regulation of cyclin-dependent protein serine/threonine kinase by cyclin degradation]
GO:0010458 [exit from mitosis]
GO:0010994 [free ubiquitin chain polymerization]
GO:0016567 [protein ubiquitination]
GO:0030071 [regulation of mitotic metaphase/anaphase transition]
GO:0031145 [anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process]
GO:0031536 [positive regulation of exit from mitosis]
GO:0031625 [ubiquitin protein ligase binding]
GO:0051301 [cell division]
GO:0051436 [negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle]
GO:0051437 [positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition]
GO:0051439 [regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle]
GO:0051488 [activation of anaphase-promoting complex activity]
GO:0061630 [ubiquitin protein ligase activity]
GO:0061631 [ubiquitin conjugating enzyme activity]
GO:0070936 [protein K48-linked ubiquitination]
GO:0070979 [protein K11-linked ubiquitination]
Show all
 140 aa
15.8 kDa 		No 0
UBE2C-005
ENSP00000243893
ENST00000243893
K4DI81 [Direct mapping]
Ubiquitin-conjugating enzyme E2 C; Ubiquitin-conjugating enzyme E2C, isoform CRA_d
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0016567 [protein ubiquitination]
GO:0030071 [regulation of mitotic metaphase/anaphase transition]
GO:0031625 [ubiquitin protein ligase binding]
GO:0061630 [ubiquitin protein ligase activity]
Show all
 50 aa
5.1 kDa 		No 0
UBE2C-006
ENSP00000333975
ENST00000352551
O00762 [Direct mapping]
Ubiquitin-conjugating enzyme E2 C
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005680 [anaphase-promoting complex]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0007094 [mitotic spindle assembly checkpoint]
GO:0008054 [negative regulation of cyclin-dependent protein serine/threonine kinase by cyclin degradation]
GO:0010458 [exit from mitosis]
GO:0010994 [free ubiquitin chain polymerization]
GO:0016567 [protein ubiquitination]
GO:0030071 [regulation of mitotic metaphase/anaphase transition]
GO:0031145 [anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process]
GO:0031536 [positive regulation of exit from mitosis]
GO:0031625 [ubiquitin protein ligase binding]
GO:0051301 [cell division]
GO:0051436 [negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle]
GO:0051437 [positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition]
GO:0051439 [regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle]
GO:0051488 [activation of anaphase-promoting complex activity]
GO:0061630 [ubiquitin protein ligase activity]
GO:0061631 [ubiquitin conjugating enzyme activity]
GO:0070936 [protein K48-linked ubiquitination]
GO:0070979 [protein K11-linked ubiquitination]
Show all
 150 aa
16.7 kDa 		No 0
UBE2C-201
ENSP00000385878
ENST00000405520
A0A0A0MSE8 [Direct mapping]
Ubiquitin-conjugating enzyme E2 C
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0016567 [protein ubiquitination]
GO:0030071 [regulation of mitotic metaphase/anaphase transition]
GO:0031625 [ubiquitin protein ligase binding]
GO:0061630 [ubiquitin protein ligase activity]
Show all
 79 aa
8.1 kDa 		No 0
UBE2C-202
ENSP00000479486
ENST00000617055
A0A087WVK1 [Direct mapping]
Ubiquitin-conjugating enzyme E2 C
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0016567 [protein ubiquitination]
GO:0030071 [regulation of mitotic metaphase/anaphase transition]
GO:0031625 [ubiquitin protein ligase binding]
GO:0061630 [ubiquitin protein ligase activity]
Show all
 132 aa
14.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.