Tissue expression of RAG2 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	RAG2
Gene description	Recombination activating gene 2
Protein class	Disease related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enriched (thyroid gland)
GTEx:	Tissue enriched (thyroid gland)
FANTOM5:	Group enriched (epididymis, thyroid gland)

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (thyroid gland)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (thyroid gland)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Group enriched (epididymis, thyroid gland)

GENE INFORMATION
Gene name	RAG2
Synonyms
Description	Recombination activating gene 2 (HGNC Symbol)
Entrez gene summary	This gene encodes a protein that is involved in the initiation of V(D)J recombination during B and T cell development. This protein forms a complex with the product of the adjacent recombination activating gene 1, and this complex can form double-strand breaks by cleaving DNA at conserved recombination signal sequences. The recombination activating gene 1 component is thought to contain most of the catalytic activity, while the N-terminal of the recombination activating gene 2 component is thought to form a six-bladed propeller in the active core that serves as a binding scaffold for the tight association of the complex with DNA. A C-terminal plant homeodomain finger-like motif in this protein is necessary for interactions with chromatin components, specifically with histone H3 that is trimethylated at lysine 4. Mutations in this gene cause Omenn syndrome, a form of severe combined immunodeficiency associated with autoimmune-like symptoms. [provided by RefSeq, Jul 2008]
Chromosome	11
Cytoband	p12
Chromosome location (bp)	36575574 - 36598279
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000175097 (version 83.38)
Entrez gene	5897
UniProt	P55895 (UniProt - Evidence at protein level)
neXtProt	NX_P55895
Antibodypedia	RAG2 antibodies

PROTEIN BROWSER

RAG2-001	RAG2-003	RAG2-004	RAG2-008	RAG2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
RAG2-001 ENSP00000308620 ENST00000311485	P55895 [Direct mapping] V(D)J recombination-activating protein 2 Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Show all	GO:0002331 [pre-B cell allelic exclusion] GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0005546 [phosphatidylinositol-4,5-bisphosphate binding] GO:0005547 [phosphatidylinositol-3,4,5-trisphosphate binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006310 [DNA recombination] GO:0008270 [zinc ion binding] GO:0016568 [chromatin modification] GO:0030183 [B cell differentiation] GO:0033077 [T cell differentiation in thymus] GO:0033151 [V(D)J recombination] GO:0035064 [methylated histone binding] GO:0035091 [phosphatidylinositol binding] GO:0043325 [phosphatidylinositol-3,4-bisphosphate binding] GO:0080025 [phosphatidylinositol-3,5-bisphosphate binding] Show all	527 aa 59.2 kDa	No	0
RAG2-003 ENSP00000436895 ENST00000527033	E9PQB9 [Direct mapping] V(D)J recombination-activating protein 2 Show all	Predicted intracellular proteins Show all	GO:0003677 [DNA binding] GO:0005634 [nucleus] GO:0006310 [DNA recombination] Show all	71 aa 8 kDa	No	0
RAG2-004 ENSP00000432174 ENST00000532616		Predicted intracellular proteins Show all		1 aa 0.1 kDa	No	0
RAG2-008 ENSP00000436327 ENST00000529083	E9PPU5 [Direct mapping] V(D)J recombination-activating protein 2 Show all	Predicted intracellular proteins Show all	GO:0003677 [DNA binding] GO:0005634 [nucleus] GO:0006310 [DNA recombination] Show all	150 aa 17 kDa	No	0
RAG2-201 ENSP00000478672 ENST00000618712	P55895 [Direct mapping] V(D)J recombination-activating protein 2 Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Show all	GO:0002326 [B cell lineage commitment] GO:0002331 [pre-B cell allelic exclusion] GO:0002358 [B cell homeostatic proliferation] GO:0002360 [T cell lineage commitment] GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0005515 [protein binding] GO:0005546 [phosphatidylinositol-4,5-bisphosphate binding] GO:0005547 [phosphatidylinositol-3,4,5-trisphosphate binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006310 [DNA recombination] GO:0008270 [zinc ion binding] GO:0016567 [protein ubiquitination] GO:0016568 [chromatin modification] GO:0030183 [B cell differentiation] GO:0030217 [T cell differentiation] GO:0033077 [T cell differentiation in thymus] GO:0033151 [V(D)J recombination] GO:0035064 [methylated histone binding] GO:0035091 [phosphatidylinositol binding] GO:0043325 [phosphatidylinositol-3,4-bisphosphate binding] GO:0046622 [positive regulation of organ growth] GO:0061630 [ubiquitin protein ligase activity] GO:0080025 [phosphatidylinositol-3,5-bisphosphate binding] Show all	527 aa 59.2 kDa	No	0