Expression of ZNF654 in cancer - Summary - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

ZNF654

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ZNF654
Gene description	Zinc finger protein 654
Protein class	Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	1
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and nuclear expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Uncertain based on 2 antibodies. HPA036172 , HPA036173
	SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in prostate cancer (unfavourable).
Prostate cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

Endometrial cancer

STAINING SUMMARY

HPA036172	HPA036173

GENE INFORMATION
Gene name	ZNF654 (HGNC Symbol)
Synonyms	FLJ10997, FLJ21142
Description	Zinc finger protein 654 (HGNC Symbol)
Entrez gene summary
Chromosome	3
Cytoband	p11.1
Chromosome location (bp)	88139104 - 88144665
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000175105 (version 83.38)
Entrez gene	55279
UniProt	Q8IZM8 (UniProt - Evidence at transcript level)
neXtProt	NX_Q8IZM8
Antibodypedia	ZNF654 antibodies

PROTEIN BROWSER

ZNF654-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ZNF654-001 ENSP00000312141 ENST00000309495	Q8IZM8 [Direct mapping] Zinc finger protein 654 Show all	Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0046872 [metal ion binding] Show all	581 aa 65.9 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.