Tissue expression of WFDC5 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	WFDC5
Gene description	WAP four-disulfide core domain 5
Protein class	Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enriched (skin)
GTEx:	Tissue enriched (skin)
FANTOM5:	Tissue enhanced (esophagus, testis, tonsil)

Protein evidence

Evidence at transcript level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (skin)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (skin)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (esophagus, testis, tonsil)

GENE INFORMATION
Gene name	WFDC5 (HGNC Symbol)
Synonyms	dJ211D12.5, WAP1
Description	WAP four-disulfide core domain 5 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the WAP-type four-disulfide core (WFDC) domain family. Most WFDC proteins contain only one WFDC domain, and this encoded protein contains two WFDC domains. The WFDC domain, or WAP signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor. Most WFDC gene members are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene belongs to the centromeric cluster. [provided by RefSeq, Jul 2008]
Chromosome	20
Cytoband	q13.12
Chromosome location (bp)	45109452 - 45115172
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000175121 (version 83.38)
Entrez gene	149708
UniProt	Q8TCV5 (UniProt - Evidence at transcript level)
neXtProt	NX_Q8TCV5
Antibodypedia	WFDC5 antibodies

PROTEIN BROWSER

WFDC5-001	WFDC5-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
WFDC5-001 ENSP00000361875 ENST00000372789	Q8TCV5 [Direct mapping] WAP four-disulfide core domain protein 5 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0004867 [serine-type endopeptidase inhibitor activity] GO:0005576 [extracellular region] GO:0010951 [negative regulation of endopeptidase activity] GO:0030414 [peptidase inhibitor activity] Show all	123 aa 13.3 kDa	Yes	0
WFDC5-002 ENSP00000312381 ENST00000307971	Q8TCV5 [Direct mapping] WAP four-disulfide core domain protein 5 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0004867 [serine-type endopeptidase inhibitor activity] GO:0005576 [extracellular region] GO:0010951 [negative regulation of endopeptidase activity] GO:0030414 [peptidase inhibitor activity] Show all	224 aa 24.2 kDa	Yes	0