Expression of PCCA in cancer - Summary - The Human Protein Atlas

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PCCA

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	PCCA
Gene description	Propionyl CoA carboxylase, alpha polypeptide
Protein class	Disease related genes Enzymes Plasma proteins Potential drug targets Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	8
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (RPTEC TERT1, SCLC-21H, U-937)
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Granular cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Supported based on 2 antibodies. HPA041716 , HPA047792
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA041716	HPA047792

GENE INFORMATION
Gene name	PCCA
Synonyms
Description	Propionyl CoA carboxylase, alpha polypeptide (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is the alpha subunit of the heterodimeric mitochondrial enzyme Propionyl-CoA carboxylase. PCCA encodes the biotin-binding region of this enzyme. Mutations in either PCCA or PCCB (encoding the beta subunit) lead to an enzyme deficiency resulting in propionic acidemia. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2010]
Chromosome	13
Cytoband	q32.3
Chromosome location (bp)	100089015 - 100530435
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000175198 (version 83.38)
Entrez gene	5095
UniProt	P05165 (UniProt - Evidence at protein level)
neXtProt	NX_P05165
Antibodypedia	PCCA antibodies

PROTEIN BROWSER

PCCA-001	PCCA-002	PCCA-003	PCCA-004	PCCA-005	PCCA-007	PCCA-201	PCCA-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PCCA-001 ENSP00000365462 ENST00000376285	P05165 [Direct mapping] Propionyl-CoA carboxylase alpha chain, mitochondrial Show all	Enzymes ENZYME proteins Ligase Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004075 [biotin carboxylase activity] GO:0004658 [propionyl-CoA carboxylase activity] GO:0005524 [ATP binding] GO:0005739 [mitochondrion] GO:0005759 [mitochondrial matrix] GO:0005829 [cytosol] GO:0006635 [fatty acid beta-oxidation] GO:0006766 [vitamin metabolic process] GO:0006767 [water-soluble vitamin metabolic process] GO:0006768 [biotin metabolic process] GO:0009374 [biotin binding] GO:0019626 [short-chain fatty acid catabolic process] GO:0019899 [enzyme binding] GO:0044255 [cellular lipid metabolic process] GO:0044281 [small molecule metabolic process] GO:0046872 [metal ion binding] Show all	728 aa 80.1 kDa	No	0
PCCA-002 ENSP00000400740 ENST00000443601	H0Y5U0 [Direct mapping] Propionyl-CoA carboxylase alpha chain, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004075 [biotin carboxylase activity] GO:0005524 [ATP binding] GO:0008152 [metabolic process] Show all	139 aa 15.6 kDa	No	0
PCCA-003 ENSP00000396050 ENST00000424527	Q5JTW6 [Direct mapping] Propionyl-CoA carboxylase alpha chain, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		149 aa 16.5 kDa	No	0
PCCA-004 ENSP00000390850 ENST00000458283	H0Y4B9 [Direct mapping] Propionyl-CoA carboxylase alpha chain, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		134 aa 14.1 kDa	No	0
PCCA-005 ENSP00000411194 ENST00000413170	H0Y798 [Direct mapping] Propionyl-CoA carboxylase alpha chain, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005576 [extracellular region] GO:0019836 [hemolysis by symbiont of host erythrocytes] Show all	84 aa 9 kDa	No	0
PCCA-007 ENSP00000399413 ENST00000428969	Q5JVH2 [Direct mapping] Propionyl-CoA carboxylase alpha chain, mitochondrial Show all	SCAMPI predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		111 aa 11.9 kDa	No	0
PCCA-201 ENSP00000365456 ENST00000376279	P05165 [Direct mapping] Propionyl-CoA carboxylase alpha chain, mitochondrial Show all	Enzymes ENZYME proteins Ligase Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004075 [biotin carboxylase activity] GO:0004658 [propionyl-CoA carboxylase activity] GO:0005524 [ATP binding] GO:0005759 [mitochondrial matrix] GO:0005829 [cytosol] GO:0006635 [fatty acid beta-oxidation] GO:0006766 [vitamin metabolic process] GO:0006767 [water-soluble vitamin metabolic process] GO:0006768 [biotin metabolic process] GO:0009374 [biotin binding] GO:0019626 [short-chain fatty acid catabolic process] GO:0019899 [enzyme binding] GO:0044255 [cellular lipid metabolic process] GO:0044281 [small molecule metabolic process] GO:0046872 [metal ion binding] Show all	681 aa 75 kDa	No	0
PCCA-202 ENSP00000365463 ENST00000376286	P05165 [Direct mapping] Propionyl-CoA carboxylase alpha chain, mitochondrial Show all	Enzymes ENZYME proteins Ligase Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004075 [biotin carboxylase activity] GO:0004658 [propionyl-CoA carboxylase activity] GO:0005524 [ATP binding] GO:0005759 [mitochondrial matrix] GO:0005829 [cytosol] GO:0006635 [fatty acid beta-oxidation] GO:0006766 [vitamin metabolic process] GO:0006767 [water-soluble vitamin metabolic process] GO:0006768 [biotin metabolic process] GO:0009374 [biotin binding] GO:0019626 [short-chain fatty acid catabolic process] GO:0019899 [enzyme binding] GO:0044255 [cellular lipid metabolic process] GO:0044281 [small molecule metabolic process] GO:0046872 [metal ion binding] Show all	702 aa 77 kDa	No	0

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