Expression of HIGD2B in cancer - Summary - The Human Protein Atlas

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HIGD2B

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	HIGD2B
Gene description	HIG1 hypoxia inducible domain family, member 2B
Protein class	Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Not detected
HPA (cell line):	Not detected
HPA (normal tissue):	Tissue enriched (testis)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Pending external verification. Caution, targets protein from more than one gene.
Reliability score	Uncertain based on 2 antibodies. HPA019016 , HPA042715
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Not detected

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA019016	HPA042715

GENE INFORMATION
Gene name	HIGD2B (HGNC Symbol)
Synonyms	HIGD2BP
Description	HIG1 hypoxia inducible domain family, member 2B (HGNC Symbol)
Entrez gene summary
Chromosome	15
Cytoband	q24.1
Chromosome location (bp)	72675783 - 72686149
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000175202 (version 83.38)
Entrez gene
UniProt	Q4VC39 (UniProt - Uncertain)
neXtProt	NX_Q4VC39
Antibodypedia	HIGD2B antibodies

PROTEIN BROWSER

HIGD2B-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
HIGD2B-001 ENSP00000307951 ENST00000311755	Q4VC39 [Direct mapping] Putative HIG1 domain family member 2B Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0016021 [integral component of membrane] Show all	106 aa 11.4 kDa	No	2

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.