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DCTN2

GENERAL INFORMATION

Gene name

 DCTN2

Gene description

 Dynactin 2 (p50)

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 8
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 2 antibodies.
HPA039715 , HPA040040
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable).
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA039715
HPA040040

GENE INFORMATION

Gene name

 DCTN2 (HGNC Symbol)

Synonyms

 DCTN-50, RBP50

Description

 Dynactin 2 (p50) (HGNC Symbol)

Entrez gene summary

 This gene encodes a 50-kD subunit of dynactin, a macromolecular complex consisting of 10-11 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit is present in 4-5 copies per dynactin molecule. It contains three short alpha-helical coiled-coil domains that may mediate association with self or other dynactin subunits. It may interact directly with the largest subunit (p150) of dynactin and may affix p150 in place. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2012]

Chromosome

 12

Cytoband

 q13.3

Chromosome location (bp)

 57530102 - 57547331

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000175203 (version 83.38)

Entrez gene

 10540

UniProt

 Q13561 (UniProt - Evidence at protein level)

neXtProt

 NX_Q13561

Antibodypedia

 DCTN2 antibodies

PROTEIN BROWSER
DCTN2-001
DCTN2-007
DCTN2-014
DCTN2-018
DCTN2-023
DCTN2-025
DCTN2-026
DCTN2-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DCTN2-001
ENSP00000447824
ENST00000548249
Q13561 [Direct mapping]
Dynactin subunit 2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0000776 [kinetochore]
GO:0003774 [motor activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0005869 [dynactin complex]
GO:0005874 [microtubule]
GO:0006996 [organelle organization]
GO:0007052 [mitotic spindle organization]
GO:0007067 [mitotic nuclear division]
GO:0008152 [metabolic process]
GO:0008283 [cell proliferation]
GO:0016020 [membrane]
GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II]
GO:0030286 [dynein complex]
GO:0030507 [spectrin binding]
GO:0031982 [vesicle]
GO:0070062 [extracellular exosome]
GO:0071539 [protein localization to centrosome]
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 401 aa
44.2 kDa 		No 0
DCTN2-007
ENSP00000449710
ENST00000550750
F8VX93 [Direct mapping]
Dynactin subunit 2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005869 [dynactin complex]
GO:0007052 [mitotic spindle organization]
GO:0007067 [mitotic nuclear division]
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 135 aa
15.1 kDa 		No 0
DCTN2-014
ENSP00000448606
ENST00000546670
F8VRV7 [Direct mapping]
Dynactin subunit 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005869 [dynactin complex]
GO:0007052 [mitotic spindle organization]
GO:0007067 [mitotic nuclear division]
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 153 aa
17.1 kDa 		No 0
DCTN2-018
ENSP00000447308
ENST00000550086
H0YHL1 [Direct mapping]
Dynactin subunit 2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005869 [dynactin complex]
GO:0007052 [mitotic spindle organization]
GO:0007067 [mitotic nuclear division]
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 128 aa
14.2 kDa 		No 0
DCTN2-023
ENSP00000448937
ENST00000546758
H0YI98 [Direct mapping]
Dynactin subunit 2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005869 [dynactin complex]
GO:0007052 [mitotic spindle organization]
GO:0007067 [mitotic nuclear division]
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 268 aa
29.3 kDa 		No 0
DCTN2-025
ENSP00000449855
ENST00000550954
F8VW18 [Direct mapping]
Dynactin subunit 2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005869 [dynactin complex]
GO:0007052 [mitotic spindle organization]
GO:0007067 [mitotic nuclear division]
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 278 aa
30.5 kDa 		No 0
DCTN2-026
ENSP00000408910
ENST00000434715
Q13561 [Direct mapping]
Dynactin subunit 2
V9HW58 [Target identity:100%; Query identity:100%]
Epididymis secretory protein Li 77
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0000776 [kinetochore]
GO:0003774 [motor activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0005869 [dynactin complex]
GO:0005874 [microtubule]
GO:0006996 [organelle organization]
GO:0007052 [mitotic spindle organization]
GO:0007067 [mitotic nuclear division]
GO:0008152 [metabolic process]
GO:0008283 [cell proliferation]
GO:0016020 [membrane]
GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II]
GO:0030286 [dynein complex]
GO:0030426 [growth cone]
GO:0030507 [spectrin binding]
GO:0031982 [vesicle]
GO:0032402 [melanosome transport]
GO:0070062 [extracellular exosome]
GO:0071539 [protein localization to centrosome]
Show all
 406 aa
44.8 kDa 		No 0
DCTN2-201
ENSP00000439376
ENST00000543672
Q13561 [Direct mapping]
Dynactin subunit 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0000776 [kinetochore]
GO:0003774 [motor activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0005869 [dynactin complex]
GO:0005874 [microtubule]
GO:0006996 [organelle organization]
GO:0007052 [mitotic spindle organization]
GO:0007067 [mitotic nuclear division]
GO:0008152 [metabolic process]
GO:0008283 [cell proliferation]
GO:0016020 [membrane]
GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II]
GO:0030286 [dynein complex]
GO:0030507 [spectrin binding]
GO:0031982 [vesicle]
GO:0070062 [extracellular exosome]
GO:0071539 [protein localization to centrosome]
Show all
 403 aa
44.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.