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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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NPPA
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    TISSUE

  • CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

NPPA

Gene description

Natriuretic peptide A

Protein class

Candidate cardiovascular disease genes
Disease related genes
Plasma proteins
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

Intracellular,Secreted

Number of transcripts

3
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Tissue enriched (glioma)
HPA (cell line):Cell line enhanced (SCLC-21H, SH-SY5Y)
HPA (normal tissue):Tissue enriched (heart muscle)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Distinct expression in heart.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Reliability score

Supported based on 1 antibody.
HPA058269
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PROGNOSTIC SUMMARY

Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Tissue enriched (glioma)

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA058269

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Few cases of breast, liver, urothelial and stomach cancers showed weak to moderate cytoplasmic or nuclear immunoreactivity. Remaining cancer tissues were negative.

GENE INFORMATION

Gene name

NPPA (HGNC Symbol)

Synonyms

ANP, PND

Description

Natriuretic peptide A (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene belongs to the natriuretic peptide family. Natriuretic peptides are implicated in the control of extracellular fluid volume and electrolyte homeostasis. This protein is synthesized as a large precursor (containing a signal peptide), which is processed to release a peptide from the N-terminus with similarity to vasoactive peptide, cardiodilatin, and another peptide from the C-terminus with natriuretic-diuretic activity. Mutations in this gene have been associated with atrial fibrillation familial type 6. This gene is located adjacent to another member of the natriuretic family of peptides on chromosome 1. [provided by RefSeq, Oct 2015]

Chromosome

1

Cytoband

p36.22

Chromosome location (bp)

11845709 - 11848345

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000175206 (version 83.38)

Entrez gene

4878

UniProt

P01160 (UniProt - Evidence at protein level)

neXtProt

NX_P01160

Antibodypedia

NPPA antibodies

PROTEIN BROWSER

NPPA-001
NPPA-002
NPPA-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

NPPA-001
ENSP00000365663
ENST00000376480
P01160 [Direct mapping]
Natriuretic peptides A Atrial natriuretic factor
Show all
   MEMSAT3 predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Candidate cardiovascular disease genes
Disease related genes
Protein evidence (Kim et al 2014)
Show all
GO:0001666 [response to hypoxia]
GO:0003085 [negative regulation of systemic arterial blood pressure]
GO:0005102 [receptor binding]
GO:0005179 [hormone activity]
GO:0005184 [neuropeptide hormone activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006182 [cGMP biosynthetic process]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0007168 [receptor guanylyl cyclase signaling pathway]
GO:0007218 [neuropeptide signaling pathway]
GO:0007565 [female pregnancy]
GO:0008217 [regulation of blood pressure]
GO:0010460 [positive regulation of heart rate]
GO:0010467 [gene expression]
GO:0014898 [cardiac muscle hypertrophy in response to stress]
GO:0030308 [negative regulation of cell growth]
GO:0032868 [response to insulin]
GO:0035994 [response to muscle stretch]
GO:0042629 [mast cell granule]
GO:0044267 [cellular protein metabolic process]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050880 [regulation of blood vessel size]
GO:0051428 [peptide hormone receptor binding]
GO:0060372 [regulation of atrial cardiac muscle cell membrane repolarization]
GO:0060452 [positive regulation of cardiac muscle contraction]
GO:0061049 [cell growth involved in cardiac muscle cell development]
GO:0071260 [cellular response to mechanical stimulus]
GO:0071855 [neuropeptide receptor binding]
GO:1901841 [regulation of high voltage-gated calcium channel activity]
GO:1902261 [positive regulation of delayed rectifier potassium channel activity]
GO:1902514 [regulation of generation of L-type calcium current]
GO:1903766 [positive regulation of potassium ion export across plasma membrane]
GO:1903815 [negative regulation of collecting lymphatic vessel constriction]
Show all
151 aa
16.4 kDa
Yes 0
NPPA-002
ENSP00000365659
ENST00000376476
B0ZBE8 [Direct mapping]
Natriuretic peptide A variant 1; Natriuretic peptides A
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Predicted intracellular proteins
Show all
GO:0005179 [hormone activity]
GO:0005576 [extracellular region]
GO:0050880 [regulation of blood vessel size]
Show all
101 aa
10.8 kDa
No 0
NPPA-201
ENSP00000483195
ENST00000610706
A0A087X094 [Direct mapping]
Natriuretic peptides A
Show all
   MEMSAT3 predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Show all
GO:0005179 [hormone activity]
GO:0005576 [extracellular region]
GO:0050880 [regulation of blood vessel size]
Show all
152 aa
16.6 kDa
Yes 0

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