Expression of CTDSP2 in cancer - Summary - The Human Protein Atlas

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CTDSP2

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CTDSP2
Gene description	CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enriched (RH-30)
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and membranous expressio in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA052607
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA052607

GENE INFORMATION
Gene name	CTDSP2 (HGNC Symbol)
Synonyms	OS4, PSR2, SCP2
Description	CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2 (HGNC Symbol)
Entrez gene summary
Chromosome	12
Cytoband	q14.1
Chromosome location (bp)	57819927 - 57846739
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000175215 (version 83.38)
Entrez gene	10106
UniProt	O14595 (UniProt - Evidence at protein level)
neXtProt	NX_O14595
Antibodypedia	CTDSP2 antibodies

PROTEIN BROWSER

CTDSP2-001	CTDSP2-003	CTDSP2-004	CTDSP2-006	CTDSP2-009	CTDSP2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CTDSP2-001 ENSP00000381148 ENST00000398073	O14595 [Direct mapping] Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2 A0A024RBA6 [Target identity:100%; Query identity:100%] CTD (Carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2, isoform CRA_c Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Show all	GO:0001933 [negative regulation of protein phosphorylation] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0006470 [protein dephosphorylation] GO:0008420 [CTD phosphatase activity] GO:0016791 [phosphatase activity] GO:0030968 [endoplasmic reticulum unfolded protein response] GO:0036498 [IRE1-mediated unfolded protein response] GO:0044267 [cellular protein metabolic process] GO:0046872 [metal ion binding] GO:2000134 [negative regulation of G1/S transition of mitotic cell cycle] Show all	271 aa 30.7 kDa	No	0
CTDSP2-003 ENSP00000447046 ENST00000548823	F8W1I1 [Direct mapping] Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2 Show all	Predicted intracellular proteins Show all		98 aa 10.9 kDa	No	0
CTDSP2-004 ENSP00000446705 ENST00000547701	F8W184 [Direct mapping] Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2 Show all	Predicted intracellular proteins Show all	GO:0016311 [dephosphorylation] GO:0016791 [phosphatase activity] Show all	119 aa 13.5 kDa	No	0
CTDSP2-006 ENSP00000448299 ENST00000550144	H0YI12 [Direct mapping] Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2 Show all	Predicted intracellular proteins Show all	GO:0016311 [dephosphorylation] GO:0016791 [phosphatase activity] Show all	182 aa 20.7 kDa	No	0
CTDSP2-009 ENSP00000448386 ENST00000549039	H0YI29 [Direct mapping] Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2 Show all	Predicted intracellular proteins Show all		125 aa 14.2 kDa	No	0
CTDSP2-201 ENSP00000480551 ENST00000622025	A0A087WWW2 [Direct mapping] Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2 Show all	Predicted intracellular proteins Show all	GO:0016311 [dephosphorylation] GO:0016791 [phosphatase activity] Show all	282 aa 31.7 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.