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ARHGAP1

GENERAL INFORMATION

Gene name

 ARHGAP1

Gene description

 Rho GTPase activating protein 1

Protein class

 Plasma proteins
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression at variable levels in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 2 antibodies.
HPA004689 , HPA008285
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable).
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA004689
HPA008285

GENE INFORMATION

Gene name

 ARHGAP1 (HGNC Symbol)

Synonyms

 CDC42GAP, p50rhoGAP, RhoGAP

Description

 Rho GTPase activating protein 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of a large family of proteins that activate Rho-type guanosine triphosphate (GTP) metabolizing enzymes. The encoded protein contains a SRC homology 3 domain and interacts with Bcl-2-associated protein family members. [provided by RefSeq, Aug 2012]

Chromosome

 11

Cytoband

 p11.2

Chromosome location (bp)

 46677080 - 46700615

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000175220 (version 83.38)

Entrez gene

 392

UniProt

 Q07960 (UniProt - Evidence at protein level)

neXtProt

 NX_Q07960

Antibodypedia

 ARHGAP1 antibodies

PROTEIN BROWSER
ARHGAP1-001
ARHGAP1-006
ARHGAP1-007

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ARHGAP1-001
ENSP00000310491
ENST00000311956
Q07960 [Direct mapping]
Rho GTPase-activating protein 1
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0001726 [ruffle]
GO:0005070 [SH3/SH2 adaptor activity]
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007266 [Rho protein signal transduction]
GO:0009967 [positive regulation of signal transduction]
GO:0017124 [SH3 domain binding]
GO:0031252 [cell leading edge]
GO:0043087 [regulation of GTPase activity]
GO:0043547 [positive regulation of GTPase activity]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051056 [regulation of small GTPase mediated signal transduction]
GO:0070062 [extracellular exosome]
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 439 aa
50.4 kDa 		No 1
ARHGAP1-006
ENSP00000432794
ENST00000525488
E9PNR6 [Direct mapping]
Rho GTPase-activating protein 1
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
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GO:0005737 [cytoplasm]
GO:0016021 [integral component of membrane]
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 192 aa
22.5 kDa 		No 1
ARHGAP1-007
ENSP00000434883
ENST00000528837
H0YE29 [Direct mapping]
Rho GTPase-activating protein 1
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   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005737 [cytoplasm]
GO:0007165 [signal transduction]
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 334 aa
38.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.