Cell atlas - CCNE2 - The Human Protein Atlas

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CCNE2

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION

GENE/PROTEIN

Dictionary

Human cell

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GENERAL INFORMATION
Gene name	CCNE2
Gene description	Cyclin E2
Protein class	Cancer-related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Not available

DATA RELIABILITY
Reliability score	Pending cell analysis.

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

GENE INFORMATION
Gene name	CCNE2 (HGNC Symbol)
Synonyms	CYCE2
Description	Cyclin E2 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2. This cyclin has been shown to specifically interact with CIP/KIP family of CDK inhibitors, and plays a role in cell cycle G1/S transition. The expression of this gene peaks at the G1-S phase and exhibits a pattern of tissue specificity distinct from that of cyclin E1. A significantly increased expression level of this gene was observed in tumor-derived cells. [provided by RefSeq, Jul 2008]
Chromosome	8
Cytoband	q22.1
Chromosome location (bp)	94879770 - 94896678
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000175305 (version 83.38)
Entrez gene	9134
UniProt	O96020 (UniProt - Evidence at protein level)
neXtProt	NX_O96020
Antibodypedia	CCNE2 antibodies

PROTEIN BROWSER

CCNE2-001	CCNE2-003	CCNE2-009	CCNE2-201	CCNE2-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CCNE2-001 ENSP00000429089 ENST00000520509	O96020 [Direct mapping] G1/S-specific cyclin-E2 A0A024R9B0 [Target identity:100%; Query identity:100%] Cyclin E2, isoform CRA_e Show all	Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Ezkurdia et al 2014) Show all	GO:0000075 [cell cycle checkpoint] GO:0000079 [regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0000082 [G1/S transition of mitotic cell cycle] GO:0000278 [mitotic cell cycle] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005829 [cytosol] GO:0006270 [DNA replication initiation] GO:0016538 [cyclin-dependent protein serine/threonine kinase regulator activity] GO:0019901 [protein kinase binding] GO:0045859 [regulation of protein kinase activity] GO:0051301 [cell division] GO:0051726 [regulation of cell cycle] Show all	404 aa 46.8 kDa	No	0
CCNE2-003 ENSP00000379437 ENST00000396133	Q8WUE3 [Direct mapping] CCNE2 protein; Cyclin E2, isoform CRA_a; G1/S-specific cyclin-E2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000082 [G1/S transition of mitotic cell cycle] GO:0005634 [nucleus] GO:0051726 [regulation of cell cycle] Show all	374 aa 43.5 kDa	No	0
CCNE2-009 ENSP00000430060 ENST00000524224	H0YBQ2 [Direct mapping] G1/S-specific cyclin-E2 Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000082 [G1/S transition of mitotic cell cycle] GO:0051726 [regulation of cell cycle] Show all	152 aa 17.8 kDa	No	0
CCNE2-201 ENSP00000309181 ENST00000308108	O96020 [Direct mapping] G1/S-specific cyclin-E2 A0A024R9B0 [Target identity:100%; Query identity:100%] Cyclin E2, isoform CRA_e Show all	Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Ezkurdia et al 2014) Show all	GO:0000075 [cell cycle checkpoint] GO:0000079 [regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0000082 [G1/S transition of mitotic cell cycle] GO:0000278 [mitotic cell cycle] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005829 [cytosol] GO:0051301 [cell division] Show all	404 aa 46.8 kDa	No	0
CCNE2-202 ENSP00000479777 ENST00000611101	I6L961 [Direct mapping] CCNE2 protein; G1/S-specific cyclin-E2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000082 [G1/S transition of mitotic cell cycle] GO:0005634 [nucleus] GO:0051726 [regulation of cell cycle] Show all	296 aa 34.3 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.