Expression of ANKS4B in cancer - Summary

GENERAL INFORMATION
Gene name	ANKS4B
Gene description	Ankyrin repeat and sterile alpha motif domain containing 4B
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Group enriched (colorectal cancer, liver cancer, pancreatic cancer, renal cancer, stomach cancer)
HPA (cell line):	Group enriched (CACO-2, HDLM-2, Hep G2)
HPA (normal tissue):	Tissue enhanced (duodenum, rectum, small intestine)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and membranous expression in gastrointestinal tract, kidney, liver and gallbladder.

ANTIBODY IHC RELIABILITY
Data reliability description	Presumed off target binding observed and disregarded. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA043523
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Group enriched (colorectal cancer, liver cancer, pancreatic cancer, renal cancer, stomach cancer)

PROTEIN EXPRESSION

STAINING SUMMARY

HPA043523

GENE INFORMATION
Gene name	ANKS4B (HGNC Symbol)
Synonyms	FLJ38819, HARP
Description	Ankyrin repeat and sterile alpha motif domain containing 4B (HGNC Symbol)
Entrez gene summary
Chromosome	16
Cytoband	p12.2
Chromosome location (bp)	21233665 - 21253845
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000175311 (version 83.38)
Entrez gene	257629
UniProt	Q8N8V4 (UniProt - Evidence at protein level)
neXtProt	NX_Q8N8V4
Antibodypedia	ANKS4B antibodies

PROTEIN BROWSER

ANKS4B-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ANKS4B-001 ENSP00000308772 ENST00000311620	Q8N8V4 [Direct mapping] Ankyrin repeat and SAM domain-containing protein 4B Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005789 [endoplasmic reticulum membrane] GO:0005886 [plasma membrane] GO:0034976 [response to endoplasmic reticulum stress] Show all	417 aa 46.6 kDa	No	0