Expression of CST6 in cancer - Summary - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

CST6

premium

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CST6
Gene description	Cystatin E/M
Protein class	Cancer-related genes Plasma proteins Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	1
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enhanced (thyroid cancer)
HPA (cell line):	Group enriched (A-431, CAPAN-2)
HPA (normal tissue):	Tissue enriched (skin)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Selective cytoplasmic expression in squamous epithelium of skin.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data.
Reliability score	Supported based on 2 antibodies. HPA044963 , CAB019316
	SHOW MORE

PROGNOSTIC SUMMARY
Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enhanced (thyroid cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA044963	CAB019316

GENE INFORMATION
Gene name	CST6
Synonyms
Description	Cystatin E/M (HGNC Symbol)
Entrez gene summary	The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions, where they appear to provide protective functions. This gene encodes a cystatin from the type 2 family, which is down-regulated in metastatic breast tumor cells as compared to primary tumor cells. Loss of expression is likely associated with the progression of a primary tumor to a metastatic phenotype. [provided by RefSeq, Jul 2008]
Chromosome	11
Cytoband	q13.1
Chromosome location (bp)	66011841 - 66013505
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000175315 (version 83.38)
Entrez gene	1474
UniProt	Q15828 (UniProt - Evidence at protein level)
neXtProt	NX_Q15828
Antibodypedia	CST6 antibodies

PROTEIN BROWSER

CST6-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CST6-001 ENSP00000311313 ENST00000312134	Q15828 [Direct mapping] Cystatin-M Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001533 [cornified envelope] GO:0004869 [cysteine-type endopeptidase inhibitor activity] GO:0008544 [epidermis development] GO:0009653 [anatomical structure morphogenesis] GO:0010951 [negative regulation of endopeptidase activity] GO:0070062 [extracellular exosome] Show all	149 aa 16.5 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.