Expression of GRAMD2 in cancer - Summary - The Human Protein Atlas

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GRAMD2

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	GRAMD2
Gene description	GRAM domain containing 2
Protein class	Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Group enriched (BEWO, SK-BR-3)
HPA (normal tissue):	Tissue enhanced (epididymis, placenta)

Protein evidence

Evidence at transcript level

Protein expression
normal tissue

Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA029435
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PROGNOSTIC SUMMARY
Prognostic marker in thyroid cancer (unfavourable).
Thyroid cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA029435

GENE INFORMATION
Gene name	GRAMD2
Synonyms
Description	GRAM domain containing 2 (HGNC Symbol)
Entrez gene summary
Chromosome	15
Cytoband	q23
Chromosome location (bp)	72159807 - 72197785
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000175318 (version 83.38)
Entrez gene	196996
UniProt	Q8IUY3 (UniProt - Evidence at transcript level)
neXtProt	NX_Q8IUY3
Antibodypedia	GRAMD2 antibodies

PROTEIN BROWSER

GRAMD2-001	GRAMD2-005	GRAMD2-008	GRAMD2-009

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GRAMD2-001 ENSP00000311657 ENST00000309731	Q8IUY3 [Direct mapping] GRAM domain-containing protein 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0016021 [integral component of membrane] Show all	354 aa 40.2 kDa	No	1
GRAMD2-005 ENSP00000457660 ENST00000564129	H3BUI8 [Direct mapping] GRAM domain-containing protein 2 Show all	Predicted intracellular proteins Show all		211 aa 24.2 kDa	No	0
GRAMD2-008 ENSP00000457088 ENST00000570275	H3BTA1 [Direct mapping] GRAM domain-containing protein 2 Show all	Predicted intracellular proteins Show all		145 aa 16.6 kDa	No	0
GRAMD2-009 ENSP00000457383 ENST00000568594	H3BTY3 [Direct mapping] GRAM domain-containing protein 2 Show all	Predicted intracellular proteins Show all		169 aa 19.5 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.