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BANF1

GENERAL INFORMATION

Gene name

 BANF1

Gene description

 Barrier to autointegration factor 1

Protein class

 Disease related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Ubiquitous nuclear and nuclear membrane expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA039242 , CAB032896
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Heart muscle

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 BANF1 (HGNC Symbol)

Synonyms

 BAF

Description

 Barrier to autointegration factor 1 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene was first identified by its ability to protect retroviruses from intramolecular integration and therefore promote intermolecular integration into the host cell genome. The protein forms a homodimer which localizes to both the nucleus and cytoplasm and is specifically associated with chromosomes during mitosis. This protein binds to double stranded DNA in a non-specific manner and also binds to LEM-domain containing proteins of the nuclear envelope. This protein is thought to facilitate nuclear reassembly by binding with both DNA and inner nuclear membrane proteins and thereby recruit chromatin to the nuclear periphery. Alternative splicing results in multiple transcript variants encoding the same protein.[provided by RefSeq, Jan 2009]

Chromosome

 11

Cytoband

 q13.1

Chromosome location (bp)

 66002079 - 66004149

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000175334 (version 83.38)

Entrez gene

 8815

UniProt

 O75531 (UniProt - Evidence at protein level)

neXtProt

 NX_O75531

Antibodypedia

 BANF1 antibodies

PROTEIN BROWSER
BANF1-001
BANF1-002
BANF1-003
BANF1-004
BANF1-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
BANF1-001
ENSP00000310275
ENST00000312175
O75531 [Direct mapping]
Barrier-to-autointegration factor Barrier-to-autointegration factor, N-terminally processed
A0A024R5H0 [Target identity:100%; Query identity:100%]
Barrier to autointegration factor 1, isoform CRA_a
Show all
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0000793 [condensed chromosome]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005694 [chromosome]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0007077 [mitotic nuclear envelope disassembly]
GO:0007084 [mitotic nuclear envelope reassembly]
GO:0009615 [response to virus]
GO:0015074 [DNA integration]
GO:0016032 [viral process]
GO:0042803 [protein homodimerization activity]
GO:0070062 [extracellular exosome]
GO:0075713 [establishment of integrated proviral latency]
Show all
 89 aa
10.1 kDa 		No 0
BANF1-002
ENSP00000416128
ENST00000445560
O75531 [Direct mapping]
Barrier-to-autointegration factor Barrier-to-autointegration factor, N-terminally processed
A0A024R5H0 [Target identity:100%; Query identity:100%]
Barrier to autointegration factor 1, isoform CRA_a
Show all
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005694 [chromosome]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0007077 [mitotic nuclear envelope disassembly]
GO:0007084 [mitotic nuclear envelope reassembly]
GO:0009615 [response to virus]
GO:0016032 [viral process]
GO:0070062 [extracellular exosome]
GO:0075713 [establishment of integrated proviral latency]
Show all
 89 aa
10.1 kDa 		No 0
BANF1-003
ENSP00000431785
ENST00000530204
E9PJJ8 [Direct mapping]
Barrier-to-autointegration factor
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
Show all
 28 aa
3 kDa 		No 0
BANF1-004
ENSP00000433760
ENST00000533166
O75531 [Direct mapping]
Barrier-to-autointegration factor Barrier-to-autointegration factor, N-terminally processed
A0A024R5H0 [Target identity:100%; Query identity:100%]
Barrier to autointegration factor 1, isoform CRA_a
Show all
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005694 [chromosome]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0007077 [mitotic nuclear envelope disassembly]
GO:0007084 [mitotic nuclear envelope reassembly]
GO:0009615 [response to virus]
GO:0016032 [viral process]
GO:0070062 [extracellular exosome]
GO:0075713 [establishment of integrated proviral latency]
Show all
 89 aa
10.1 kDa 		No 0
BANF1-005
ENSP00000432867
ENST00000527348
O75531 [Direct mapping]
Barrier-to-autointegration factor Barrier-to-autointegration factor, N-terminally processed
A0A024R5H0 [Target identity:100%; Query identity:100%]
Barrier to autointegration factor 1, isoform CRA_a
Show all
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005694 [chromosome]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0007077 [mitotic nuclear envelope disassembly]
GO:0007084 [mitotic nuclear envelope reassembly]
GO:0009615 [response to virus]
GO:0016032 [viral process]
GO:0070062 [extracellular exosome]
GO:0075713 [establishment of integrated proviral latency]
Show all
 89 aa
10.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.