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CHRNA7

GENERAL INFORMATION

Gene name

 CHRNA7

Gene description

 Cholinergic receptor, nicotinic, alpha 7 (neuronal)

Protein class

 FDA approved drug targets
Predicted membrane proteins
Transporters

Predicted localization

 Membrane

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Cell line enhanced (RT4, SH-SY5Y)
HPA (normal tissue):Tissue enhanced (adrenal gland, small intestine)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic expression in essentially all cells except in lymphoid cells, CNS and gastrointestinal tract.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA029422 , CAB033624
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA029422
CAB033624

GENE INFORMATION

Gene name

 CHRNA7

Synonyms

Description

 Cholinergic receptor, nicotinic, alpha 7 (neuronal) (HGNC Symbol)

Entrez gene summary

 The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The nAChRs are thought to be hetero-pentamers composed of homologous subunits. The proposed structure for each subunit is a conserved N-terminal extracellular domain followed by three conserved transmembrane domains, a variable cytoplasmic loop, a fourth conserved transmembrane domain, and a short C-terminal extracellular region. The protein encoded by this gene forms a homo-oligomeric channel, displays marked permeability to calcium ions and is a major component of brain nicotinic receptors that are blocked by, and highly sensitive to, alpha-bungarotoxin. Once this receptor binds acetylcholine, it undergoes an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. This gene is located in a region identified as a major susceptibility locus for juvenile myoclonic epilepsy and a chromosomal location involved in the genetic transmission of schizophrenia. An evolutionarily recent partial duplication event in this region results in a hybrid containing sequence from this gene and a novel FAM7A gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012]

Chromosome

 15

Cytoband

 q13.3

Chromosome location (bp)

 32030488 - 32172521

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000175344 (version 83.38)

Entrez gene

 1139

UniProt

 P36544 (UniProt - Evidence at protein level)

neXtProt

 NX_P36544

Antibodypedia

 CHRNA7 antibodies

PROTEIN BROWSER
CHRNA7-001
CHRNA7-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CHRNA7-001
ENSP00000303727
ENST00000306901
P36544 [Direct mapping]
Neuronal acetylcholine receptor subunit alpha-7
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Transporters
   Transporter channels and pores
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   4TM proteins predicted by MDM
FDA approved drug targets
   Small molecule drugs
Show all
GO:0000187 [activation of MAPK activity]
GO:0001540 [beta-amyloid binding]
GO:0001666 [response to hypoxia]
GO:0004889 [acetylcholine-activated cation-selective channel activity]
GO:0005230 [extracellular ligand-gated ion channel activity]
GO:0005886 [plasma membrane]
GO:0005892 [acetylcholine-gated channel complex]
GO:0006810 [transport]
GO:0006811 [ion transport]
GO:0006816 [calcium ion transport]
GO:0006874 [cellular calcium ion homeostasis]
GO:0007165 [signal transduction]
GO:0007268 [synaptic transmission]
GO:0007271 [synaptic transmission, cholinergic]
GO:0007613 [memory]
GO:0008284 [positive regulation of cell proliferation]
GO:0015464 [acetylcholine receptor activity]
GO:0015643 [toxic substance binding]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0017081 [chloride channel regulator activity]
GO:0022848 [acetylcholine-gated cation channel activity]
GO:0030054 [cell junction]
GO:0032720 [negative regulation of tumor necrosis factor production]
GO:0034220 [ion transmembrane transport]
GO:0035094 [response to nicotine]
GO:0042166 [acetylcholine binding]
GO:0042391 [regulation of membrane potential]
GO:0042803 [protein homodimerization activity]
GO:0043005 [neuron projection]
GO:0045202 [synapse]
GO:0045211 [postsynaptic membrane]
GO:0045766 [positive regulation of angiogenesis]
GO:0050890 [cognition]
GO:0098655 [cation transmembrane transport]
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 502 aa
56.4 kDa 		Yes 4
CHRNA7-003
ENSP00000407546
ENST00000454250
P36544 [Direct mapping]
Neuronal acetylcholine receptor subunit alpha-7
Show all
Transporters
   Transporter channels and pores
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   4TM proteins predicted by MDM
FDA approved drug targets
   Small molecule drugs
Show all
GO:0000187 [activation of MAPK activity]
GO:0001540 [beta-amyloid binding]
GO:0001666 [response to hypoxia]
GO:0004889 [acetylcholine-activated cation-selective channel activity]
GO:0005230 [extracellular ligand-gated ion channel activity]
GO:0005886 [plasma membrane]
GO:0005892 [acetylcholine-gated channel complex]
GO:0006810 [transport]
GO:0006811 [ion transport]
GO:0006816 [calcium ion transport]
GO:0006874 [cellular calcium ion homeostasis]
GO:0007165 [signal transduction]
GO:0007268 [synaptic transmission]
GO:0007271 [synaptic transmission, cholinergic]
GO:0007613 [memory]
GO:0008284 [positive regulation of cell proliferation]
GO:0015464 [acetylcholine receptor activity]
GO:0015643 [toxic substance binding]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0017081 [chloride channel regulator activity]
GO:0022848 [acetylcholine-gated cation channel activity]
GO:0030054 [cell junction]
GO:0032720 [negative regulation of tumor necrosis factor production]
GO:0034220 [ion transmembrane transport]
GO:0035094 [response to nicotine]
GO:0042166 [acetylcholine binding]
GO:0042391 [regulation of membrane potential]
GO:0042803 [protein homodimerization activity]
GO:0043005 [neuron projection]
GO:0045202 [synapse]
GO:0045211 [postsynaptic membrane]
GO:0045766 [positive regulation of angiogenesis]
GO:0050890 [cognition]
GO:0098655 [cation transmembrane transport]
Show all
 531 aa
59.2 kDa 		Yes 4

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.