Expression of EIF3F in cancer - Summary - The Human Protein Atlas

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EIF3F

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	EIF3F
Gene description	Eukaryotic translation initiation factor 3, subunit F
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification. Caution, targets protein from more than one gene.
Reliability score	Approved based on 1 antibody. HPA049250
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable).
Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA049250

GENE INFORMATION
Gene name	EIF3F (HGNC Symbol)
Synonyms	eIF3-epsilon, eIF3-p47, eIF3f, EIF3S5
Description	Eukaryotic translation initiation factor 3, subunit F (HGNC Symbol)
Entrez gene summary
Chromosome	11
Cytoband	p15.4
Chromosome location (bp)	7970251 - 8001862
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000175390 (version 83.38)
Entrez gene	8665
UniProt	O00303 (UniProt - Evidence at protein level)
neXtProt	NX_O00303
Antibodypedia	EIF3F antibodies

PROTEIN BROWSER

EIF3F-001	EIF3F-009	EIF3F-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
EIF3F-001 ENSP00000431800 ENST00000533626	O00303 [Direct mapping] Eukaryotic translation initiation factor 3 subunit F Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001731 [formation of translation preinitiation complex] GO:0003743 [translation initiation factor activity] GO:0004843 [ubiquitin-specific protease activity] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0005852 [eukaryotic translation initiation factor 3 complex] GO:0006412 [translation] GO:0006413 [translational initiation] GO:0006446 [regulation of translational initiation] GO:0010467 [gene expression] GO:0016020 [membrane] GO:0016282 [eukaryotic 43S preinitiation complex] GO:0016579 [protein deubiquitination] GO:0031369 [translation initiation factor binding] GO:0033290 [eukaryotic 48S preinitiation complex] GO:0044267 [cellular protein metabolic process] GO:0071541 [eukaryotic translation initiation factor 3 complex, eIF3m] Show all	357 aa 37.6 kDa	No	0
EIF3F-009 ENSP00000434286 ENST00000531572	H0YDT6 [Direct mapping] Eukaryotic translation initiation factor 3 subunit F Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		100 aa 10.8 kDa	No	0
EIF3F-201 ENSP00000310040 ENST00000309828	O00303 [Direct mapping] Eukaryotic translation initiation factor 3 subunit F Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001731 [formation of translation preinitiation complex] GO:0003743 [translation initiation factor activity] GO:0004843 [ubiquitin-specific protease activity] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0005852 [eukaryotic translation initiation factor 3 complex] GO:0006412 [translation] GO:0006413 [translational initiation] GO:0006446 [regulation of translational initiation] GO:0010467 [gene expression] GO:0016020 [membrane] GO:0016282 [eukaryotic 43S preinitiation complex] GO:0016579 [protein deubiquitination] GO:0031369 [translation initiation factor binding] GO:0033290 [eukaryotic 48S preinitiation complex] GO:0044267 [cellular protein metabolic process] GO:0071541 [eukaryotic translation initiation factor 3 complex, eIF3m] Show all	357 aa 37.6 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.