Expression of CCDC14 in cancer - Summary - The Human Protein Atlas

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CCDC14

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CCDC14
Gene description	Coiled-coil domain containing 14
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	10
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Uncertain based on 2 antibodies. HPA035278 , HPA035279
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), urothelial cancer (favourable), prostate cancer (unfavourable), liver cancer (unfavourable) and head and neck cancer (favourable).
Renal cancer p<0.001 Urothelial cancer p<0.001 Prostate cancer p<0.001 Liver cancer p<0.001 Head and neck cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA035278	HPA035279

GENE INFORMATION
Gene name	CCDC14 (HGNC Symbol)
Synonyms	DKFZp434L1050, FLJ12892
Description	Coiled-coil domain containing 14 (HGNC Symbol)
Entrez gene summary
Chromosome	3
Cytoband	q21.1
Chromosome location (bp)	123897305 - 123961408
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000175455 (version 83.38)
Entrez gene	64770
UniProt	Q49A88 (UniProt - Evidence at protein level)
neXtProt	NX_Q49A88
Antibodypedia	CCDC14 antibodies

PROTEIN BROWSER

CCDC14-001	CCDC14-004	CCDC14-009	CCDC14-010	CCDC14-011	CCDC14-017	CCDC14-020	CCDC14-022	CCDC14-023	CCDC14-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CCDC14-001 ENSP00000395706 ENST00000433542	Q49A88 [Direct mapping] Coiled-coil domain-containing protein 14 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005813 [centrosome] GO:0021762 [substantia nigra development] Show all	912 aa 101.5 kDa	No	0
CCDC14-004 ENSP00000386866 ENST00000409697	J3QT39 [Direct mapping] Coiled-coil domain containing 14, isoform CRA_c; Coiled-coil domain-containing protein 14 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		905 aa 100.6 kDa	No	0
CCDC14-009 ENSP00000387962 ENST00000434954	C9JWZ1 [Direct mapping] Coiled-coil domain-containing protein 14 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		117 aa 12.6 kDa	No	0
CCDC14-010 ENSP00000414655 ENST00000426152	C9JSI8 [Direct mapping] Coiled-coil domain-containing protein 14 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		174 aa 19.4 kDa	No	0
CCDC14-011 ENSP00000400957 ENST00000419247	C9JU82 [Direct mapping] Coiled-coil domain-containing protein 14 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		312 aa 35.3 kDa	No	0
CCDC14-017 ENSP00000418403 ENST00000489746	Q49A88 [Direct mapping] Coiled-coil domain-containing protein 14 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005813 [centrosome] GO:0021762 [substantia nigra development] Show all	753 aa 83.6 kDa	No	0
CCDC14-020 ENSP00000420768 ENST00000479903	H7C5T3 [Direct mapping] Coiled-coil domain-containing protein 14 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		257 aa 29.6 kDa	No	0
CCDC14-022 ENSP00000418002 ENST00000485727	Q49A88 [Direct mapping] Coiled-coil domain-containing protein 14 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005813 [centrosome] GO:0021762 [substantia nigra development] Show all	753 aa 83.6 kDa	No	0
CCDC14-023 ENSP00000312031 ENST00000310351	A0A0A0MR27 [Direct mapping] Coiled-coil domain-containing protein 14 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		864 aa 95.8 kDa	No	0
CCDC14-201 ENSP00000420180 ENST00000488653	Q49A88 [Direct mapping] Coiled-coil domain-containing protein 14 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005813 [centrosome] GO:0021762 [substantia nigra development] Show all	912 aa 101.5 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.