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SART1

GENERAL INFORMATION

Gene name

 SART1

Gene description

 Squamous cell carcinoma antigen recognized by T cells 1

Protein class

 Cancer-related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Nuclear expression in most cell types.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Supported based on 2 antibodies.
HPA031188 , HPA031189
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Placenta

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 SART1 (HGNC Symbol)

Synonyms

 Ara1, SNRNP110, Snu66

Description

 Squamous cell carcinoma antigen recognized by T cells 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes two proteins, the SART1(800) protein expressed in the nucleus of the majority of proliferating cells, and the SART1(259) protein expressed in the cytosol of epithelial cancers. The SART1(259) protein is translated by the mechanism of -1 frameshifting during posttranscriptional regulation; its full-length sequence is not published yet. The two encoded proteins are thought to be involved in the regulation of proliferation. Both proteins have tumor-rejection antigens. The SART1(259) protein possesses tumor epitopes capable of inducing HLA-A2402-restricted cytotoxic T lymphocytes in cancer patients. This SART1(259) antigen may be useful in specific immunotherapy for cancer patients and may serve as a paradigmatic tool for the diagnosis and treatment of patients with atopy. The SART1(259) protein is found to be essential for the recruitment of the tri-snRNP to the pre-spliceosome in the spliceosome assembly pathway. [provided by RefSeq, Jul 2008]

Chromosome

 11

Cytoband

 q13.1

Chromosome location (bp)

 65961689 - 65979828

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000175467 (version 83.38)

Entrez gene

 9092

UniProt

 O43290 (UniProt - Evidence at protein level)

neXtProt

 NX_O43290

Antibodypedia

 SART1 antibodies

PROTEIN BROWSER
SART1-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SART1-001
ENSP00000310448
ENST00000312397
O43290 [Direct mapping]
U4/U6.U5 tri-snRNP-associated protein 1
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Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000387 [spliceosomal snRNP assembly]
GO:0000398 [mRNA splicing, via spliceosome]
GO:0000481 [maturation of 5S rRNA]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0007050 [cell cycle arrest]
GO:0015030 [Cajal body]
GO:0044822 [poly(A) RNA binding]
GO:0045292 [mRNA cis splicing, via spliceosome]
GO:0045585 [positive regulation of cytotoxic T cell differentiation]
GO:0046540 [U4/U6 x U5 tri-snRNP complex]
GO:0071013 [catalytic step 2 spliceosome]
GO:0097193 [intrinsic apoptotic signaling pathway]
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 800 aa
90.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.