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PPP2R2D

GENERAL INFORMATION

Gene name

 PPP2R2D

Gene description

 Protein phosphatase 2, regulatory subunit B, delta

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in most cell types.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Caution, targets protein from more than one gene.

Reliability score

 Approved based on 2 antibodies.
HPA042122 , HPA042770
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PROGNOSTIC SUMMARY
Prognostic marker in colorectal cancer (unfavourable).
Colorectal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA042122
HPA042770

GENE INFORMATION

Gene name

 PPP2R2D (HGNC Symbol)

Synonyms

 MDS026

Description

 Protein phosphatase 2, regulatory subunit B, delta (HGNC Symbol)

Entrez gene summary

Chromosome

 10

Cytoband

 q26.3

Chromosome location (bp)

 131900644 - 131959834

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000175470 (version 83.38)

Entrez gene

 55844

UniProt

 Q66LE6 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q66LE6

Antibodypedia

 PPP2R2D antibodies

PROTEIN BROWSER
PPP2R2D-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PPP2R2D-001
ENSP00000399970
ENST00000455566
Q66LE6 [Direct mapping]
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000159 [protein phosphatase type 2A complex]
GO:0000278 [mitotic cell cycle]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0007067 [mitotic nuclear division]
GO:0008601 [protein phosphatase type 2A regulator activity]
GO:0010458 [exit from mitosis]
GO:0034047 [regulation of protein phosphatase type 2A activity]
GO:0051301 [cell division]
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 453 aa
52 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.