Cell atlas - DPP10 - The Human Protein Atlas

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DPP10

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Nucleus
	Vesicles

Human cell
	Cytosol
	Nucleoplasm
	Vesicles

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GENERAL INFORMATION
Gene name	DPP10
Gene description	Dipeptidyl-peptidase 10 (non-functional)
Protein class	Disease related genes Enzymes Potential drug targets Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleus. In addition localized to the cytosol & vesicles.
RNA cell category	Cell line enhanced (SCLC-21H, RT4, AF22, SH-SY5Y, HMC-1, NTERA-2)
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleus (approved)
Additional location	In addition localized to the Vesicles (approved), Cytosol (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA048767
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (SCLC-21H, RT4, AF22, SH-SY5Y, HMC-1, NTERA-2) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleus. In addition localized to the cytosol & vesicles.

Main location

Nucleus (approved)

Additional location

Vesicles (approved), Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA048767	RT4	No staining
	HPA048767	SH-SY5Y	Nucleus
	HPA048767	SH-SY5Y	Vesicles
	HPA048767	U-2 OS	Nucleoplasm
	HPA048767	U-2 OS	Cytosol

GENE INFORMATION
Gene name	DPP10 (HGNC Symbol)
Synonyms	DPRP3
Description	Dipeptidyl-peptidase 10 (non-functional) (HGNC Symbol)
Entrez gene summary	This gene encodes a single-pass type II membrane protein that is a member of the S9B family in clan SC of the serine proteases. This protein has no detectable protease activity, most likely due to the absence of the conserved serine residue normally present in the catalytic domain of serine proteases. However, it does bind specific voltage-gated potassium channels and alters their expression and biophysical properties. Mutations in this gene have been associated with asthma. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Chromosome	2
Cytoband	q14.1
Chromosome location (bp)	114442299 - 115845752
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000175497 (version 83.38)
Entrez gene	57628
UniProt	Q8N608 (UniProt - Evidence at protein level)
neXtProt	NX_Q8N608
Antibodypedia	DPP10 antibodies

PROTEIN BROWSER

DPP10-001	DPP10-002	DPP10-005	DPP10-007	DPP10-008	DPP10-009	DPP10-011

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DPP10-001 ENSP00000386565 ENST00000410059	Q8N608 [Direct mapping] Inactive dipeptidyl peptidase 10 Show all	Enzymes Peptidases Serine-type peptidases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005886 [plasma membrane] GO:0006508 [proteolysis] GO:0008236 [serine-type peptidase activity] GO:0015459 [potassium channel regulator activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0072659 [protein localization to plasma membrane] GO:0090004 [positive regulation of establishment of protein localization to plasma membrane] GO:1901379 [regulation of potassium ion transmembrane transport] Show all	796 aa 90.9 kDa	No	1
DPP10-002 ENSP00000387038 ENST00000409163	Q8N608 [Direct mapping] Inactive dipeptidyl peptidase 10 Show all	Enzymes Peptidases Serine-type peptidases Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005886 [plasma membrane] GO:0006508 [proteolysis] GO:0008236 [serine-type peptidase activity] GO:0015459 [potassium channel regulator activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0072659 [protein localization to plasma membrane] GO:0090004 [positive regulation of establishment of protein localization to plasma membrane] GO:1901379 [regulation of potassium ion transmembrane transport] Show all	746 aa 85.5 kDa	No	0
DPP10-005 ENSP00000309066 ENST00000310323	Q8N608 [Direct mapping] Inactive dipeptidyl peptidase 10 Show all	Enzymes Peptidases Serine-type peptidases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005886 [plasma membrane] GO:0006508 [proteolysis] GO:0008236 [serine-type peptidase activity] GO:0015459 [potassium channel regulator activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0072659 [protein localization to plasma membrane] GO:0090004 [positive regulation of establishment of protein localization to plasma membrane] GO:1901379 [regulation of potassium ion transmembrane transport] Show all	789 aa 90.1 kDa	No	1
DPP10-007 ENSP00000376855 ENST00000393147	Q8N608 [Direct mapping] Inactive dipeptidyl peptidase 10 Show all	Enzymes Peptidases Serine-type peptidases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005886 [plasma membrane] GO:0006508 [proteolysis] GO:0008236 [serine-type peptidase activity] GO:0015459 [potassium channel regulator activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0072659 [protein localization to plasma membrane] GO:0090004 [positive regulation of establishment of protein localization to plasma membrane] GO:1901379 [regulation of potassium ion transmembrane transport] Show all	800 aa 91.1 kDa	No	1
DPP10-008 ENSP00000391092 ENST00000436732	C9J4M8 [Direct mapping] Inactive dipeptidyl peptidase 10 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006508 [proteolysis] Show all	60 aa 7 kDa	No	0
DPP10-009 ENSP00000376854 ENST00000393146	J3KPP1 [Direct mapping] Inactive dipeptidyl peptidase 10 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0006508 [proteolysis] GO:0016021 [integral component of membrane] Show all	259 aa 29.6 kDa	No	1
DPP10-011 ENSP00000402499 ENST00000419287	J3KQK8 [Direct mapping] Inactive dipeptidyl peptidase 10 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006508 [proteolysis] Show all	97 aa 11.1 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.