Expression of DRAP1 in cancer - Summary - The Human Protein Atlas

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DRAP1

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	DRAP1
Gene description	DR1-associated protein 1 (negative cofactor 2 alpha)
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Nuclear and cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA006790
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and thyroid cancer (favourable).
Renal cancer p<0.001 Thyroid cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA006790

GENE INFORMATION
Gene name	DRAP1 (HGNC Symbol)
Synonyms	NC2-alpha
Description	DR1-associated protein 1 (negative cofactor 2 alpha) (HGNC Symbol)
Entrez gene summary	Transcriptional repression is a general mechanism for regulating transcriptional initiation in organisms ranging from yeast to humans. Accurate initiation of transcription from eukaryotic protein-encoding genes requires the assembly of a large multiprotein complex consisting of RNA polymerase II and general transcription factors such as TFIIA, TFIIB, and TFIID. DR1 is a repressor that interacts with the TATA-binding protein (TBP) of TFIID and prevents the formation of an active transcription complex by precluding the entry of TFIIA and/or TFIIB into the preinitiation complex. The protein encoded by this gene is a corepressor of transcription that interacts with DR1 to enhance DR1-mediated repression. The interaction between this corepressor and DR1 is required for corepressor function and appears to stabilize the TBP-DR1-DNA complex. [provided by RefSeq, Jul 2008]
Chromosome	11
Cytoband	q13.1
Chromosome location (bp)	65919257 - 65921561
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000175550 (version 83.38)
Entrez gene	10589
UniProt	Q14919 (UniProt - Evidence at protein level)
neXtProt	NX_Q14919
Antibodypedia	DRAP1 antibodies

PROTEIN BROWSER

DRAP1-001	DRAP1-003	DRAP1-004	DRAP1-007	DRAP1-008

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DRAP1-001 ENSP00000307850 ENST00000312515	Q14919 [Direct mapping] Dr1-associated corepressor Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0003714 [transcription corepressor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0008134 [transcription factor binding] GO:0046982 [protein heterodimerization activity] Show all	205 aa 22.3 kDa	No	0
DRAP1-003 ENSP00000432445 ENST00000532933	E9PQX9 [Direct mapping] Dr1-associated corepressor Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] GO:0046982 [protein heterodimerization activity] Show all	185 aa 20 kDa	No	0
DRAP1-004 ENSP00000437225 ENST00000525501	E9PNC7 [Direct mapping] Dr1-associated corepressor Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] GO:0046982 [protein heterodimerization activity] Show all	156 aa 16.7 kDa	No	0
DRAP1-007 ENSP00000437287 ENST00000527119	E9PMW2 [Direct mapping] Dr1-associated corepressor Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0046982 [protein heterodimerization activity] Show all	161 aa 17.5 kDa	No	0
DRAP1-008 ENSP00000366190 ENST00000376991	C9JCC6 [Direct mapping] Dr1-associated corepressor Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] GO:0046982 [protein heterodimerization activity] Show all	212 aa 23.2 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.