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P2RY2

GENERAL INFORMATION

Gene name

 P2RY2

Gene description

 Purinergic receptor P2Y, G-protein coupled, 2

Protein class

 FDA approved drug targets
G-protein coupled receptors
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (esophagus)
GTEx:Tissue enhanced (esophagus, skeletal muscle)
FANTOM5:Mixed

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in several different cell types.

DATA RELIABILITY

Data reliability
description

 Pending external verification.

Reliability score

 Uncertain based on 1 antibody.
CAB022642
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Spleen

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (esophagus)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (esophagus, skeletal muscle)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed

GENE INFORMATION

Gene name

 P2RY2 (HGNC Symbol)

Synonyms

 P2U

Description

 Purinergic receptor P2Y, G-protein coupled, 2 (HGNC Symbol)

Entrez gene summary

 The product of this gene belongs to the family of P2 receptors, which is activated by extracellular nucleotides and subdivided into P2X ligand-gated ion channels and P2Y G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor, found on many cell types, is activated by ATP and UTP and is reported to be overexpressed on some cancer cell types. It is involved in many cellular functions, such as proliferation, apoptosis and inflammation. Three transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Mar 2013]

Chromosome

 11

Cytoband

 q13.4

Chromosome location (bp)

 73218298 - 73236352

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000175591 (version 83.38)

Entrez gene

 5029

UniProt

 P41231 (UniProt - Evidence at transcript level)

neXtProt

 NX_P41231

Antibodypedia

 P2RY2 antibodies

PROTEIN BROWSER
P2RY2-001
P2RY2-002
P2RY2-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
P2RY2-001
ENSP00000310305
ENST00000311131
P41231 [Direct mapping]
P2Y purinoceptor 2
Show all
G-protein coupled receptors
   GPCRs excl olfactory receptors
   Adenosine and adenine nucleotide receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
FDA approved drug targets
   Small molecule drugs
Show all
GO:0001701 [in utero embryonic development]
GO:0004872 [receptor activity]
GO:0004930 [G-protein coupled receptor activity]
GO:0005524 [ATP binding]
GO:0005739 [mitochondrion]
GO:0005764 [lysosome]
GO:0005769 [early endosome]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006873 [cellular ion homeostasis]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007200 [phospholipase C-activating G-protein coupled receptor signaling pathway]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0007568 [aging]
GO:0010976 [positive regulation of neuron projection development]
GO:0014911 [positive regulation of smooth muscle cell migration]
GO:0016021 [integral component of membrane]
GO:0016323 [basolateral plasma membrane]
GO:0016324 [apical plasma membrane]
GO:0019233 [sensory perception of pain]
GO:0030279 [negative regulation of ossification]
GO:0032308 [positive regulation of prostaglandin secretion]
GO:0032722 [positive regulation of chemokine production]
GO:0035589 [G-protein coupled purinergic nucleotide receptor signaling pathway]
GO:0042060 [wound healing]
GO:0042312 [regulation of vasodilation]
GO:0045028 [G-protein coupled purinergic nucleotide receptor activity]
GO:0045030 [UTP-activated nucleotide receptor activity]
GO:0060406 [positive regulation of penile erection]
GO:0070257 [positive regulation of mucus secretion]
GO:0070848 [response to growth factor]
GO:0071222 [cellular response to lipopolysaccharide]
GO:0071347 [cellular response to interleukin-1]
GO:0071415 [cellular response to purine-containing compound]
Show all
 377 aa
42.3 kDa 		No 7
P2RY2-002
ENSP00000377222
ENST00000393597
P41231 [Direct mapping]
P2Y purinoceptor 2
Show all
G-protein coupled receptors
   GPCRs excl olfactory receptors
   Adenosine and adenine nucleotide receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
FDA approved drug targets
   Small molecule drugs
Show all
GO:0004872 [receptor activity]
GO:0004930 [G-protein coupled receptor activity]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006873 [cellular ion homeostasis]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007200 [phospholipase C-activating G-protein coupled receptor signaling pathway]
GO:0016021 [integral component of membrane]
GO:0035589 [G-protein coupled purinergic nucleotide receptor signaling pathway]
GO:0045028 [G-protein coupled purinergic nucleotide receptor activity]
GO:0070257 [positive regulation of mucus secretion]
Show all
 377 aa
42.3 kDa 		No 7
P2RY2-003
ENSP00000377221
ENST00000393596
P41231 [Direct mapping]
P2Y purinoceptor 2
Show all
G-protein coupled receptors
   GPCRs excl olfactory receptors
   Adenosine and adenine nucleotide receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
FDA approved drug targets
   Small molecule drugs
Show all
GO:0004872 [receptor activity]
GO:0004930 [G-protein coupled receptor activity]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006873 [cellular ion homeostasis]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007200 [phospholipase C-activating G-protein coupled receptor signaling pathway]
GO:0016021 [integral component of membrane]
GO:0035589 [G-protein coupled purinergic nucleotide receptor signaling pathway]
GO:0045028 [G-protein coupled purinergic nucleotide receptor activity]
GO:0070257 [positive regulation of mucus secretion]
Show all
 377 aa
42.3 kDa 		No 7

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.