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FOSL1

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GENERAL INFORMATION

Gene name

 FOSL1

Gene description

 FOS-like antigen 1

Protein class

 Cancer-related genes
Plasma proteins
Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the nucleoplasm.

RNA cell category

 Cell line enhanced (WM-115, PC-3)

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleoplasm (validated)

DATA RELIABILITY

Reliability score

 Validated based on 2 antibodies.
CAB004396 , HPA066901
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (WM-115, PC-3)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the nucleoplasm.

Main location

 Nucleoplasm (validated)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
CAB004396 A-431 Nucleoplasm
CAB004396 U-2 OS Nucleoplasm
CAB004396 U-251 MG Nucleoplasm
HPA066901 U-2 OS Nucleoplasm
HPA066901 U-251 MG Nucleoplasm

GENE INFORMATION

Gene name

 FOSL1 (HGNC Symbol)

Synonyms

 fra-1

Description

 FOS-like antigen 1 (HGNC Symbol)

Entrez gene summary

 The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]

Chromosome

 11

Cytoband

 q13.1

Chromosome location (bp)

 65892049 - 65900573

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000175592 (version 83.38)

Entrez gene

 8061

UniProt

 P15407 (UniProt - Evidence at protein level)

neXtProt

 NX_P15407

Antibodypedia

 FOSL1 antibodies

PROTEIN BROWSER
FOSL1-001
FOSL1-002
FOSL1-004
FOSL1-005
FOSL1-006

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
FOSL1-001
ENSP00000310170
ENST00000312562
P15407 [Direct mapping]
Fos-related antigen 1
Show all
Predicted intracellular proteins
Plasma proteins
Transcription factors
   Basic domains
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0000982 [transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001701 [in utero embryonic development]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006935 [chemotaxis]
GO:0006968 [cellular defense response]
GO:0007296 [vitellogenesis]
GO:0007565 [female pregnancy]
GO:0007612 [learning]
GO:0008284 [positive regulation of cell proliferation]
GO:0008285 [negative regulation of cell proliferation]
GO:0009612 [response to mechanical stimulus]
GO:0009615 [response to virus]
GO:0009629 [response to gravity]
GO:0014070 [response to organic cyclic compound]
GO:0031668 [cellular response to extracellular stimulus]
GO:0032570 [response to progesterone]
GO:0034097 [response to cytokine]
GO:0042493 [response to drug]
GO:0042542 [response to hydrogen peroxide]
GO:0042734 [presynaptic membrane]
GO:0043005 [neuron projection]
GO:0043065 [positive regulation of apoptotic process]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043565 [sequence-specific DNA binding]
GO:0045787 [positive regulation of cell cycle]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity]
GO:0051412 [response to corticosterone]
GO:0051591 [response to cAMP]
GO:0060674 [placenta blood vessel development]
GO:2000144 [positive regulation of DNA-templated transcription, initiation]
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 271 aa
29.4 kDa 		No 0
FOSL1-002
ENSP00000393302
ENST00000448083
P15407 [Direct mapping]
Fos-related antigen 1
Show all
Predicted intracellular proteins
Plasma proteins
Transcription factors
   Basic domains
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0000982 [transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006935 [chemotaxis]
GO:0006968 [cellular defense response]
GO:0008284 [positive regulation of cell proliferation]
GO:0009615 [response to virus]
GO:2000144 [positive regulation of DNA-templated transcription, initiation]
Show all
 169 aa
17.6 kDa 		No 0
FOSL1-004
ENSP00000434350
ENST00000534222
E9PQT6 [Direct mapping]
Fos-related antigen 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 13 aa
1.4 kDa 		No 0
FOSL1-005
ENSP00000436276
ENST00000531493
E9PPX2 [Direct mapping]
Fos-related antigen 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
Show all
 235 aa
25 kDa 		No 0
FOSL1-006
ENSP00000431594
ENST00000532401
E9PKL5 [Direct mapping]
Fos-related antigen 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
Show all
 135 aa
14.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.