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CCDC85B

GENERAL INFORMATION

Gene name

 CCDC85B

Gene description

 Coiled-coil domain containing 85B

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Granular cytoplasmic expression in several tissues with variable levels.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Uncertain based on 1 antibody.
HPA054415
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA054415

GENE INFORMATION

Gene name

 CCDC85B (HGNC Symbol)

Synonyms

 DIPA

Description

 Coiled-coil domain containing 85B (HGNC Symbol)

Entrez gene summary

 Hepatitis delta virus (HDV) is a pathogenic human virus whose RNA genome and replication cycle resemble those of plant viroids. Delta-interacting protein A (DIPA), a cellular gene product, has been found to have homology to hepatitis delta virus antigen (HDAg). DIPA interacts with the viral antigen, HDAg, and can affect HDV replication in vitro. [provided by RefSeq, Jul 2008]

Chromosome

 11

Cytoband

 q13.1

Chromosome location (bp)

 65890112 - 65891635

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000175602 (version 83.38)

Entrez gene

 11007

UniProt

 Q15834 (UniProt - Evidence at protein level)

neXtProt

 NX_Q15834

Antibodypedia

 CCDC85B antibodies

PROTEIN BROWSER
CCDC85B-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CCDC85B-001
ENSP00000311695
ENST00000312579
Q15834 [Direct mapping]
Coiled-coil domain-containing protein 85B
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0006351 [transcription, DNA-templated]
GO:0030154 [cell differentiation]
GO:0030308 [negative regulation of cell growth]
GO:0045599 [negative regulation of fat cell differentiation]
GO:0045892 [negative regulation of transcription, DNA-templated]
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 202 aa
22.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.