Expression of TOM1L2 in cancer - Summary - The Human Protein Atlas

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TOM1L2

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TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	TOM1L2
Gene description	Target of myb1 like 2 membrane trafficking protein
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	10
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most cells.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Supported based on 2 antibodies. HPA022541 , HPA023304
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable), head and neck cancer (favourable), pancreatic cancer (favourable) and ovarian cancer (unfavourable).
Renal cancer p<0.001 Head and neck cancer p<0.001 Pancreatic cancer p<0.001 Ovarian cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA022541	HPA023304

GENE INFORMATION
Gene name	TOM1L2
Synonyms
Description	Target of myb1 like 2 membrane trafficking protein (HGNC Symbol)
Entrez gene summary
Chromosome	17
Cytoband	p11.2
Chromosome location (bp)	17843511 - 17972422
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000175662 (version 83.38)
Entrez gene	146691
UniProt	Q6ZVM7 (UniProt - Evidence at protein level)
neXtProt	NX_Q6ZVM7
Antibodypedia	TOM1L2 antibodies

PROTEIN BROWSER

TOM1L2-001	TOM1L2-002	TOM1L2-003	TOM1L2-004	TOM1L2-005	TOM1L2-007	TOM1L2-008	TOM1L2-009	TOM1L2-010	TOM1L2-012

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TOM1L2-001 ENSP00000368818 ENST00000379504	Q6ZVM7 [Direct mapping] TOM1-like protein 2 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0006886 [intracellular protein transport] GO:0007165 [signal transduction] GO:0019901 [protein kinase binding] GO:0030276 [clathrin binding] GO:0045839 [negative regulation of mitotic nuclear division] GO:0070062 [extracellular exosome] Show all	507 aa 55.6 kDa	No	0
TOM1L2-002 ENSP00000464297 ENST00000581396	Q6ZVM7 [Direct mapping] TOM1-like protein 2 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0006886 [intracellular protein transport] GO:0007165 [signal transduction] GO:0019901 [protein kinase binding] GO:0030276 [clathrin binding] GO:0045839 [negative regulation of mitotic nuclear division] GO:0070062 [extracellular exosome] Show all	457 aa 50 kDa	No	0
TOM1L2-003 ENSP00000463313 ENST00000478943	Q6ZVM7 [Direct mapping] TOM1-like protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0006886 [intracellular protein transport] GO:0007165 [signal transduction] GO:0019901 [protein kinase binding] GO:0030276 [clathrin binding] GO:0045839 [negative regulation of mitotic nuclear division] GO:0070062 [extracellular exosome] Show all	240 aa 26.1 kDa	No	0
TOM1L2-004 ENSP00000379088 ENST00000395739	Q6ZVM7 [Direct mapping] TOM1-like protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0006886 [intracellular protein transport] GO:0007165 [signal transduction] GO:0019901 [protein kinase binding] GO:0030276 [clathrin binding] GO:0045839 [negative regulation of mitotic nuclear division] GO:0070062 [extracellular exosome] Show all	462 aa 50.5 kDa	No	0
TOM1L2-005 ENSP00000465677 ENST00000468944	K7EKL6 [Direct mapping] TOM1-like protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		39 aa 4.3 kDa	No	0
TOM1L2-007 ENSP00000438621 ENST00000535933	Q6ZVM7 [Direct mapping] TOM1-like protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0006886 [intracellular protein transport] GO:0007165 [signal transduction] GO:0019901 [protein kinase binding] GO:0030276 [clathrin binding] GO:0045839 [negative regulation of mitotic nuclear division] GO:0070062 [extracellular exosome] Show all	483 aa 53.4 kDa	No	0
TOM1L2-008 ENSP00000445188 ENST00000542206	F5H3S6 [Direct mapping] TOM1-like protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005622 [intracellular] GO:0006886 [intracellular protein transport] Show all	388 aa 42.7 kDa	No	0
TOM1L2-009 ENSP00000437655 ENST00000540946	B7Z2U2 [Direct mapping] TOM1-like protein 2; cDNA FLJ54050, highly similar to Homo sapiens target of myb1-like 2 (TOM1L2), transcript variant 2, mRNA Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005622 [intracellular] GO:0006886 [intracellular protein transport] Show all	389 aa 42.9 kDa	No	0
TOM1L2-010 ENSP00000312860 ENST00000318094	Q6ZVM7 [Direct mapping] TOM1-like protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0006886 [intracellular protein transport] GO:0007165 [signal transduction] GO:0019901 [protein kinase binding] GO:0030276 [clathrin binding] GO:0045839 [negative regulation of mitotic nuclear division] GO:0070062 [extracellular exosome] Show all	462 aa 50.5 kDa	No	0
TOM1L2-012 ENSP00000466863 ENST00000579586	K7ENB0 [Direct mapping] TOM1-like protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005622 [intracellular] GO:0006886 [intracellular protein transport] Show all	83 aa 9.5 kDa	No	0

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