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KDF1

GENERAL INFORMATION

Gene name

 KDF1

Gene description

 Keratinocyte differentiation factor 1

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Cell line enhanced (A-431, BEWO, CAPAN-2, HaCaT, hTCEpi, SK-BR-3)
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Pending external verification.

Reliability score

 Uncertain based on 1 antibody.
HPA028639
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable) and urothelial cancer (favourable).
Renal cancer p<0.001
Urothelial cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA028639

GENE INFORMATION

Gene name

 KDF1 (HGNC Symbol)

Synonyms

 C1orf172, FLJ34633, RP11-344H11.3

Description

 Keratinocyte differentiation factor 1 (HGNC Symbol)

Entrez gene summary

Chromosome

 1

Cytoband

 p36.11

Chromosome location (bp)

 26949562 - 26960406

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000175707 (version 83.38)

Entrez gene

 126695

UniProt

 Q8NAX2 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q8NAX2

Antibodypedia

 KDF1 antibodies

PROTEIN BROWSER
KDF1-001
KDF1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
KDF1-001
ENSP00000319179
ENST00000320567
Q8NAX2 [Direct mapping]
Keratinocyte differentiation factor 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0003334 [keratinocyte development]
GO:0005737 [cytoplasm]
GO:0005938 [cell cortex]
GO:0010482 [regulation of epidermal cell division]
GO:0010839 [negative regulation of keratinocyte proliferation]
GO:0016331 [morphogenesis of embryonic epithelium]
GO:0030054 [cell junction]
GO:0031252 [cell leading edge]
GO:0045606 [positive regulation of epidermal cell differentiation]
GO:0048589 [developmental growth]
GO:0060887 [limb epidermis development]
GO:0061436 [establishment of skin barrier]
GO:2000647 [negative regulation of stem cell proliferation]
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 398 aa
43.6 kDa 		No 0
KDF1-201
ENSP00000481107
ENST00000616918
Q68D65 [Direct mapping]
Keratinocyte differentiation factor 1; Putative uncharacterized protein DKFZp686B17277
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 207 aa
22.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.