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MLXIP

GENERAL INFORMATION

Gene name

 MLXIP

Gene description

 MLX interacting protein

Protein class

 Predicted intracellular proteins
Predicted secreted proteins
Transcription factors

Predicted localization

 Intracellular,Secreted

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 General cytoplasmic expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA023084
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Skeletal muscle

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 MLXIP (HGNC Symbol)

Synonyms

 bHLHe36, KIAA0867, MIR, MONDOA

Description

 MLX interacting protein (HGNC Symbol)

Entrez gene summary

 This gene encodes a protein that functions as part of a heterodimer to activate transcription. The encoded protein forms a heterodimer with Max-like protein X (MLX) and is involved in the regulation of genes in response to cellular glucose levels. [provided by RefSeq, Mar 2014]

Chromosome

 12

Cytoband

 q24.31

Chromosome location (bp)

 122078722 - 122147347

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000175727 (version 83.38)

Entrez gene

 22877

UniProt

 Q9HAP2 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9HAP2

Antibodypedia

 MLXIP antibodies

PROTEIN BROWSER
MLXIP-001
MLXIP-003
MLXIP-005
MLXIP-009
MLXIP-011
MLXIP-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MLXIP-001
ENSP00000312834
ENST00000319080
Q9HAP2 [Direct mapping]
MLX-interacting protein
Show all
Predicted intracellular proteins
Transcription factors
   Basic domains
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005741 [mitochondrial outer membrane]
GO:0006351 [transcription, DNA-templated]
GO:0006913 [nucleocytoplasmic transport]
GO:0046983 [protein dimerization activity]
GO:1900402 [regulation of carbohydrate metabolic process by regulation of transcription from RNA polymerase II promoter]
Show all
 919 aa
101.2 kDa 		No 0
MLXIP-003
ENSP00000440769
ENST00000538698
Q9HAP2 [Direct mapping]
MLX-interacting protein
Show all
Predicted intracellular proteins
Transcription factors
   Basic domains
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0005741 [mitochondrial outer membrane]
GO:0006351 [transcription, DNA-templated]
GO:0046983 [protein dimerization activity]
GO:1900402 [regulation of carbohydrate metabolic process by regulation of transcription from RNA polymerase II promoter]
Show all
 526 aa
56.8 kDa 		No 0
MLXIP-005
ENSP00000438206
ENST00000535430
F5H321 [Direct mapping]
MLX-interacting protein
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0006355 [regulation of transcription, DNA-templated]
Show all
 74 aa
8.4 kDa 		No 0
MLXIP-009
ENSP00000445891
ENST00000366272
F5H0V4 [Direct mapping]
MLX-interacting protein
Show all
   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0046983 [protein dimerization activity]
Show all
 308 aa
33.3 kDa 		Yes 0
MLXIP-011
ENSP00000444507
ENST00000542417
H0YGR9 [Direct mapping]
MLX-interacting protein
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0046983 [protein dimerization activity]
Show all
 171 aa
18.8 kDa 		No 0
MLXIP-201
ENSP00000366236
ENST00000377037
Q9HAP2 [Direct mapping]
MLX-interacting protein
Show all
Predicted intracellular proteins
Transcription factors
   Basic domains
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0005741 [mitochondrial outer membrane]
GO:0006351 [transcription, DNA-templated]
GO:0046983 [protein dimerization activity]
GO:1900402 [regulation of carbohydrate metabolic process by regulation of transcription from RNA polymerase II promoter]
Show all
 217 aa
22.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.