Expression of CTDNEP1 in cancer - Summary - The Human Protein Atlas

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CTDNEP1

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CTDNEP1
Gene description	CTD nuclear envelope phosphatase 1
Protein class	Enzymes Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	8
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Uncertain based on 1 antibody. HPA037439
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PROGNOSTIC SUMMARY
Prognostic marker in pancreatic cancer (favourable) and endometrial cancer (favourable).
Pancreatic cancer p<0.001 Endometrial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA037439

GENE INFORMATION
Gene name	CTDNEP1 (HGNC Symbol)
Synonyms	DULLARD, HSA011916, NET56
Description	CTD nuclear envelope phosphatase 1 (HGNC Symbol)
Entrez gene summary
Chromosome	17
Cytoband	p13.1
Chromosome location (bp)	7243591 - 7252491
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000175826 (version 83.38)
Entrez gene	23399
UniProt	O95476 (UniProt - Evidence at protein level)
neXtProt	NX_O95476
Antibodypedia	CTDNEP1 antibodies

PROTEIN BROWSER

CTDNEP1-001	CTDNEP1-002	CTDNEP1-003	CTDNEP1-005	CTDNEP1-006	CTDNEP1-007	CTDNEP1-009	CTDNEP1-012

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CTDNEP1-001 ENSP00000460683 ENST00000574322	O95476 [Direct mapping] CTD nuclear envelope phosphatase 1 Show all	Enzymes ENZYME proteins Hydrolases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000278 [mitotic cell cycle] GO:0004722 [protein serine/threonine phosphatase activity] GO:0005515 [protein binding] GO:0005635 [nuclear envelope] GO:0005737 [cytoplasm] GO:0005789 [endoplasmic reticulum membrane] GO:0006470 [protein dephosphorylation] GO:0006998 [nuclear envelope organization] GO:0007077 [mitotic nuclear envelope disassembly] GO:0010867 [positive regulation of triglyceride biosynthetic process] GO:0016021 [integral component of membrane] GO:0016791 [phosphatase activity] GO:0031965 [nuclear membrane] GO:0034504 [protein localization to nucleus] GO:0071595 [Nem1-Spo7 phosphatase complex] Show all	244 aa 28.4 kDa	No	0
CTDNEP1-002 ENSP00000461749 ENST00000573600	O95476 [Direct mapping] CTD nuclear envelope phosphatase 1 Show all	Enzymes ENZYME proteins Hydrolases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000278 [mitotic cell cycle] GO:0004722 [protein serine/threonine phosphatase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005635 [nuclear envelope] GO:0005737 [cytoplasm] GO:0005789 [endoplasmic reticulum membrane] GO:0006470 [protein dephosphorylation] GO:0006998 [nuclear envelope organization] GO:0007077 [mitotic nuclear envelope disassembly] GO:0007276 [gamete generation] GO:0007498 [mesoderm development] GO:0010867 [positive regulation of triglyceride biosynthetic process] GO:0016021 [integral component of membrane] GO:0016791 [phosphatase activity] GO:0031965 [nuclear membrane] GO:0034504 [protein localization to nucleus] GO:0071595 [Nem1-Spo7 phosphatase complex] GO:0090263 [positive regulation of canonical Wnt signaling pathway] Show all	244 aa 28.4 kDa	No	0
CTDNEP1-003 ENSP00000321732 ENST00000318988	O95476 [Direct mapping] CTD nuclear envelope phosphatase 1 Show all	Enzymes ENZYME proteins Hydrolases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000278 [mitotic cell cycle] GO:0004722 [protein serine/threonine phosphatase activity] GO:0005515 [protein binding] GO:0005635 [nuclear envelope] GO:0005737 [cytoplasm] GO:0005789 [endoplasmic reticulum membrane] GO:0006470 [protein dephosphorylation] GO:0006998 [nuclear envelope organization] GO:0007077 [mitotic nuclear envelope disassembly] GO:0010867 [positive regulation of triglyceride biosynthetic process] GO:0016021 [integral component of membrane] GO:0016791 [phosphatase activity] GO:0031965 [nuclear membrane] GO:0034504 [protein localization to nucleus] GO:0071595 [Nem1-Spo7 phosphatase complex] Show all	244 aa 28.4 kDa	No	0
CTDNEP1-005 ENSP00000461122 ENST00000575783	I3L4B2 [Direct mapping] CTD nuclear envelope phosphatase 1 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0016311 [dephosphorylation] GO:0016791 [phosphatase activity] Show all	223 aa 25.8 kDa	No	0
CTDNEP1-006 ENSP00000458408 ENST00000571409	I3L0X6 [Direct mapping] CTD nuclear envelope phosphatase 1 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		125 aa 14.9 kDa	No	0
CTDNEP1-007 ENSP00000459866 ENST00000572043	I3L2R5 [Direct mapping] CTD nuclear envelope phosphatase 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0016311 [dephosphorylation] GO:0016791 [phosphatase activity] Show all	111 aa 12.7 kDa	No	0
CTDNEP1-009 ENSP00000458763 ENST00000576613	I3L1D9 [Direct mapping] CTD nuclear envelope phosphatase 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] GO:0016311 [dephosphorylation] GO:0016791 [phosphatase activity] Show all	202 aa 23 kDa	No	1
CTDNEP1-012 ENSP00000460527 ENST00000570828	I3L3K5 [Direct mapping] CTD nuclear envelope phosphatase 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0016311 [dephosphorylation] GO:0016791 [phosphatase activity] Show all	208 aa 23.8 kDa	No	0

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