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BAIAP2

GENERAL INFORMATION

Gene name

 BAIAP2

Gene description

 BAI1-associated protein 2

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 17
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 2 antibodies.
HPA023310 , HPA027421
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PROGNOSTIC SUMMARY
Prognostic marker in urothelial cancer (unfavourable).
Urothelial cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA023310
HPA027421

GENE INFORMATION

Gene name

 BAIAP2 (HGNC Symbol)

Synonyms

 BAP2

Description

 BAI1-associated protein 2 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene has been identified as a brain-specific angiogenesis inhibitor (BAI1)-binding protein. This adaptor protein links membrane bound G-proteins to cytoplasmic effector proteins. This protein functions as an insulin receptor tyrosine kinase substrate and suggests a role for insulin in the central nervous system. It also associates with a downstream effector of Rho small G proteins, which is associated with the formation of stress fibers and cytokinesis. This protein is involved in lamellipodia and filopodia formation in motile cells and may affect neuronal growth-cone guidance. This protein has also been identified as interacting with the dentatorubral-pallidoluysian atrophy gene, which is associated with an autosomal dominant neurodegenerative disease. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Jan 2009]

Chromosome

 17

Cytoband

 q25.3

Chromosome location (bp)

 81035122 - 81117432

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000175866 (version 83.38)

Entrez gene

 10458

UniProt

 Q9UQB8 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UQB8

Antibodypedia

 BAIAP2 antibodies

PROTEIN BROWSER
«
BAIAP2-001
BAIAP2-002
BAIAP2-003
BAIAP2-004
BAIAP2-006
BAIAP2-007
BAIAP2-009
BAIAP2-010
BAIAP2-012
BAIAP2-014
BAIAP2-015
BAIAP2-016
BAIAP2-017
BAIAP2-018
BAIAP2-026
BAIAP2-027
BAIAP2-028
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
BAIAP2-001
ENSP00000401022
ENST00000428708
Q9UQB8 [Direct mapping]
Brain-specific angiogenesis inhibitor 1-associated protein 2
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001726 [ruffle]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0007009 [plasma membrane organization]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007409 [axonogenesis]
GO:0008022 [protein C-terminus binding]
GO:0008093 [cytoskeletal adaptor activity]
GO:0008286 [insulin receptor signaling pathway]
GO:0008360 [regulation of cell shape]
GO:0009617 [response to bacterium]
GO:0015629 [actin cytoskeleton]
GO:0030175 [filopodium]
GO:0030838 [positive regulation of actin filament polymerization]
GO:0032956 [regulation of actin cytoskeleton organization]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0042802 [identical protein binding]
GO:0045087 [innate immune response]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0051017 [actin filament bundle assembly]
GO:0051764 [actin crosslink formation]
GO:0070062 [extracellular exosome]
GO:0070064 [proline-rich region binding]
GO:2000251 [positive regulation of actin cytoskeleton reorganization]
Show all
 534 aa
59 kDa 		No 0
BAIAP2-002
ENSP00000315685
ENST00000321280
Q9UQB8 [Direct mapping]
Brain-specific angiogenesis inhibitor 1-associated protein 2
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001726 [ruffle]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0007009 [plasma membrane organization]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007409 [axonogenesis]
GO:0008022 [protein C-terminus binding]
GO:0008093 [cytoskeletal adaptor activity]
GO:0008286 [insulin receptor signaling pathway]
GO:0008360 [regulation of cell shape]
GO:0009617 [response to bacterium]
GO:0015629 [actin cytoskeleton]
GO:0030175 [filopodium]
GO:0030838 [positive regulation of actin filament polymerization]
GO:0032956 [regulation of actin cytoskeleton organization]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0042802 [identical protein binding]
GO:0045087 [innate immune response]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0051017 [actin filament bundle assembly]
GO:0051764 [actin crosslink formation]
GO:0070062 [extracellular exosome]
GO:0070064 [proline-rich region binding]
GO:2000251 [positive regulation of actin cytoskeleton reorganization]
Show all
 521 aa
57.4 kDa 		No 0
BAIAP2-003
ENSP00000316338
ENST00000321300
Q9UQB8 [Direct mapping]
Brain-specific angiogenesis inhibitor 1-associated protein 2
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001726 [ruffle]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0007009 [plasma membrane organization]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007409 [axonogenesis]
GO:0008022 [protein C-terminus binding]
GO:0008093 [cytoskeletal adaptor activity]
GO:0008286 [insulin receptor signaling pathway]
GO:0008360 [regulation of cell shape]
GO:0009617 [response to bacterium]
GO:0014069 [postsynaptic density]
GO:0015629 [actin cytoskeleton]
GO:0016358 [dendrite development]
GO:0030141 [secretory granule]
GO:0030165 [PDZ domain binding]
GO:0030175 [filopodium]
GO:0030838 [positive regulation of actin filament polymerization]
GO:0032956 [regulation of actin cytoskeleton organization]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0042802 [identical protein binding]
GO:0043005 [neuron projection]
GO:0043025 [neuronal cell body]
GO:0043197 [dendritic spine]
GO:0045087 [innate immune response]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048167 [regulation of synaptic plasticity]
GO:0051017 [actin filament bundle assembly]
GO:0051764 [actin crosslink formation]
GO:0061003 [positive regulation of dendritic spine morphogenesis]
GO:0070062 [extracellular exosome]
GO:0070064 [proline-rich region binding]
GO:0097481 [neuronal postsynaptic density]
GO:2000251 [positive regulation of actin cytoskeleton reorganization]
Show all
 552 aa
60.9 kDa 		No 0
BAIAP2-004
ENSP00000458964
ENST00000575712
Q9UQB8 [Direct mapping]
Brain-specific angiogenesis inhibitor 1-associated protein 2
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001726 [ruffle]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0007009 [plasma membrane organization]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007409 [axonogenesis]
GO:0008022 [protein C-terminus binding]
GO:0008093 [cytoskeletal adaptor activity]
GO:0008286 [insulin receptor signaling pathway]
GO:0008360 [regulation of cell shape]
GO:0009617 [response to bacterium]
GO:0015629 [actin cytoskeleton]
GO:0030175 [filopodium]
GO:0030838 [positive regulation of actin filament polymerization]
GO:0032956 [regulation of actin cytoskeleton organization]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0042802 [identical protein binding]
GO:0045087 [innate immune response]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0051017 [actin filament bundle assembly]
GO:0051764 [actin crosslink formation]
GO:0070062 [extracellular exosome]
GO:0070064 [proline-rich region binding]
GO:2000251 [positive regulation of actin cytoskeleton reorganization]
Show all
 512 aa
56.6 kDa 		No 0
BAIAP2-006
ENSP00000391837
ENST00000416299
B4DWA1 [Direct mapping]
Brain-specific angiogenesis inhibitor 1-associated protein 2; cDNA FLJ55181, highly similar to Brain-specific angiogenesis inhibitor1-associated protein 2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0007009 [plasma membrane organization]
GO:0008093 [cytoskeletal adaptor activity]
GO:0030838 [positive regulation of actin filament polymerization]
GO:0051017 [actin filament bundle assembly]
GO:0051764 [actin crosslink formation]
GO:2000251 [positive regulation of actin cytoskeleton reorganization]
Show all
 375 aa
40.7 kDa 		No 0
BAIAP2-007
ENSP00000413069
ENST00000435091
Q9UQB8 [Direct mapping]
Brain-specific angiogenesis inhibitor 1-associated protein 2
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001726 [ruffle]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0007009 [plasma membrane organization]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007409 [axonogenesis]
GO:0008022 [protein C-terminus binding]
GO:0008093 [cytoskeletal adaptor activity]
GO:0008286 [insulin receptor signaling pathway]
GO:0008360 [regulation of cell shape]
GO:0009617 [response to bacterium]
GO:0015629 [actin cytoskeleton]
GO:0030175 [filopodium]
GO:0030838 [positive regulation of actin filament polymerization]
GO:0032956 [regulation of actin cytoskeleton organization]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0042802 [identical protein binding]
GO:0045087 [innate immune response]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0051017 [actin filament bundle assembly]
GO:0051764 [actin crosslink formation]
GO:0070062 [extracellular exosome]
GO:0070064 [proline-rich region binding]
GO:2000251 [positive regulation of actin cytoskeleton reorganization]
Show all
 520 aa
57.4 kDa 		No 0
BAIAP2-009
ENSP00000461144
ENST00000575245
I3L4C2 [Direct mapping]
Brain-specific angiogenesis inhibitor 1-associated protein 2
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   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0007009 [plasma membrane organization]
GO:0008093 [cytoskeletal adaptor activity]
GO:0030838 [positive regulation of actin filament polymerization]
GO:0051017 [actin filament bundle assembly]
GO:0051764 [actin crosslink formation]
GO:2000251 [positive regulation of actin cytoskeleton reorganization]
Show all
 553 aa
61.4 kDa 		No 0
BAIAP2-010
ENSP00000458202
ENST00000571530
I3L0M4 [Direct mapping]
Brain-specific angiogenesis inhibitor 1-associated protein 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0007009 [plasma membrane organization]
GO:0030838 [positive regulation of actin filament polymerization]
GO:0051017 [actin filament bundle assembly]
GO:0051764 [actin crosslink formation]
GO:2000251 [positive regulation of actin cytoskeleton reorganization]
Show all
 140 aa
16 kDa 		No 0
BAIAP2-012
ENSP00000460131
ENST00000572918
I3L327 [Direct mapping]
Brain-specific angiogenesis inhibitor 1-associated protein 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0007009 [plasma membrane organization]
GO:0030838 [positive regulation of actin filament polymerization]
GO:0051017 [actin filament bundle assembly]
GO:0051764 [actin crosslink formation]
GO:2000251 [positive regulation of actin cytoskeleton reorganization]
Show all
 175 aa
20.1 kDa 		No 0
BAIAP2-014
ENSP00000458494
ENST00000575989
I3L113 [Direct mapping]
Brain-specific angiogenesis inhibitor 1-associated protein 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0007009 [plasma membrane organization]
GO:0030838 [positive regulation of actin filament polymerization]
GO:0051017 [actin filament bundle assembly]
GO:0051764 [actin crosslink formation]
GO:2000251 [positive regulation of actin cytoskeleton reorganization]
Show all
 79 aa
9.1 kDa 		No 0
BAIAP2-015
ENSP00000458522
ENST00000575958
I3L125 [Direct mapping]
Brain-specific angiogenesis inhibitor 1-associated protein 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0007009 [plasma membrane organization]
GO:0030838 [positive regulation of actin filament polymerization]
GO:0051017 [actin filament bundle assembly]
GO:0051764 [actin crosslink formation]
GO:2000251 [positive regulation of actin cytoskeleton reorganization]
Show all
 135 aa
15.6 kDa 		No 0
BAIAP2-016
ENSP00000461736
ENST00000573659
I3L526 [Direct mapping]
Brain-specific angiogenesis inhibitor 1-associated protein 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0007009 [plasma membrane organization]
GO:0030838 [positive regulation of actin filament polymerization]
GO:0051017 [actin filament bundle assembly]
GO:0051764 [actin crosslink formation]
GO:2000251 [positive regulation of actin cytoskeleton reorganization]
Show all
 114 aa
13.1 kDa 		No 0
BAIAP2-017
ENSP00000459787
ENST00000572073
I3L2M4 [Direct mapping]
Brain-specific angiogenesis inhibitor 1-associated protein 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0007009 [plasma membrane organization]
GO:0030838 [positive regulation of actin filament polymerization]
GO:0051017 [actin filament bundle assembly]
GO:0051764 [actin crosslink formation]
GO:2000251 [positive regulation of actin cytoskeleton reorganization]
Show all
 234 aa
26.1 kDa 		No 0
BAIAP2-018
ENSP00000458735
ENST00000573677
I3L1C8 [Direct mapping]
Brain-specific angiogenesis inhibitor 1-associated protein 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0007009 [plasma membrane organization]
GO:0030838 [positive regulation of actin filament polymerization]
GO:0051017 [actin filament bundle assembly]
GO:0051764 [actin crosslink formation]
GO:2000251 [positive regulation of actin cytoskeleton reorganization]
Show all
 180 aa
20.6 kDa 		No 0
BAIAP2-026
ENSP00000458440
ENST00000576756
I3L0Y9 [Direct mapping]
Brain-specific angiogenesis inhibitor 1-associated protein 2
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   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0030838 [positive regulation of actin filament polymerization]
GO:0051017 [actin filament bundle assembly]
GO:0051764 [actin crosslink formation]
GO:2000251 [positive regulation of actin cytoskeleton reorganization]
Show all
 130 aa
13.6 kDa 		No 0
BAIAP2-027
ENSP00000461101
ENST00000575841
I3L4A3 [Direct mapping]
Brain-specific angiogenesis inhibitor 1-associated protein 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0007009 [plasma membrane organization]
GO:0030838 [positive regulation of actin filament polymerization]
GO:0051017 [actin filament bundle assembly]
GO:0051764 [actin crosslink formation]
GO:2000251 [positive regulation of actin cytoskeleton reorganization]
Show all
 97 aa
10.9 kDa 		No 0
BAIAP2-028
ENSP00000460350
ENST00000572498
I3L3C6 [Direct mapping]
Brain-specific angiogenesis inhibitor 1-associated protein 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0030838 [positive regulation of actin filament polymerization]
GO:0051017 [actin filament bundle assembly]
GO:0051764 [actin crosslink formation]
GO:2000251 [positive regulation of actin cytoskeleton reorganization]
Show all
 216 aa
23.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.