Expression of CALCB in cancer - Summary - The Human Protein Atlas

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CALCB

TISSUE

CELL

PATHOLOGY

GENERAL INFORMATION
Gene name	CALCB
Gene description	Calcitonin-related polypeptide beta
Protein class	Plasma proteins Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	3
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enhanced (endometrial cancer)
HPA (cell line):	Cell line enhanced (HEK93, Karpas-707, SH-SY5Y, U-266/70)
HPA (normal tissue):	Tissue enriched (thyroid gland)

Protein evidence

Evidence at protein level

ANTIBODY IHC RELIABILITY
Reliability score	Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (unfavourable).
Endometrial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enhanced (endometrial cancer)

PROTEIN EXPRESSION
Pending cancer tissue analysis
STAINING SUMMARY

GENE INFORMATION
Gene name	CALCB (HGNC Symbol)
Synonyms	CALC2, CGRP-II, FLJ30166
Description	Calcitonin-related polypeptide beta (HGNC Symbol)
Entrez gene summary
Chromosome	11
Cytoband	p15.2
Chromosome location (bp)	14904997 - 15082342
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000175868 (version 83.38)
Entrez gene	797
UniProt	P10092 (UniProt - Evidence at protein level)
neXtProt	NX_P10092
Antibodypedia	CALCB antibodies

PROTEIN BROWSER

CALCB-001	CALCB-002	CALCB-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CALCB-001 ENSP00000428882 ENST00000523376	E7ESF5 [Direct mapping] Calcitonin gene-related peptide 2 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005179 [hormone activity] GO:0005576 [extracellular region] Show all	138 aa 14.9 kDa	Yes	0
CALCB-002 ENSP00000346017 ENST00000324229	P10092 [Direct mapping] Calcitonin gene-related peptide 2 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005179 [hormone activity] GO:0005184 [neuropeptide hormone activity] GO:0005576 [extracellular region] GO:0005623 [cell] GO:0006874 [cellular calcium ion homeostasis] GO:0007165 [signal transduction] GO:0098779 [mitophagy in response to mitochondrial depolarization] Show all	127 aa 13.7 kDa	Yes	0
CALCB-003 ENSP00000433490 ENST00000533448	P10092 [Direct mapping] Calcitonin gene-related peptide 2 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005179 [hormone activity] GO:0005184 [neuropeptide hormone activity] GO:0005576 [extracellular region] GO:0005623 [cell] GO:0006874 [cellular calcium ion homeostasis] GO:0007165 [signal transduction] GO:0098779 [mitophagy in response to mitochondrial depolarization] Show all	127 aa 13.7 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.