Expression of LRRN1 in cancer - Summary - The Human Protein Atlas

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LRRN1

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	LRRN1
Gene description	Leucine rich repeat neuronal 1
Protein class	Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (AF22, CAPAN-2, NTERA-2)
HPA (normal tissue):	Tissue enhanced (cerebral cortex)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA011071
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA011071

Cancer	Cancer staining	Protein expression of normal tissue
Breast cancer
Carcinoid
Cervical cancer
Colorectal cancer
Endometrial cancer
Glioma
Head and neck cancer
Liver cancer
Lung cancer
Lymphoma

Cancer	Cancer staining	Protein expression of normal tissue
Melanoma
Ovarian cancer
Pancreatic cancer
Prostate cancer
Renal cancer
Skin cancer
Stomach cancer
Testis cancer
Thyroid cancer
Urothelial cancer

Staining summary	Most malignancies showed moderate cytoplasmic positivity in a majority of cases. Most cases of malignant lymphomas, colorectal, breast, prostate, lung and renal cancers were weakly stained or negative.

GENE INFORMATION
Gene name	LRRN1 (HGNC Symbol)
Synonyms	FIGLER3
Description	Leucine rich repeat neuronal 1 (HGNC Symbol)
Entrez gene summary
Chromosome	3
Cytoband	p26.2
Chromosome location (bp)	3799437 - 3847703
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000175928 (version 83.38)
Entrez gene	57633
UniProt	Q6UXK5 (UniProt - Evidence at protein level)
neXtProt	NX_Q6UXK5
Antibodypedia	LRRN1 antibodies

PROTEIN BROWSER

LRRN1-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
LRRN1-001 ENSP00000314901 ENST00000319331	Q6UXK5 [Direct mapping] Leucine-rich repeat neuronal protein 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0016021 [integral component of membrane] GO:0051965 [positive regulation of synapse assembly] Show all	716 aa 80.7 kDa	Yes	1

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.