Expression of KLHL38 in cancer - Summary

GENERAL INFORMATION
Gene name	KLHL38
Gene description	Kelch-like family member 38
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enhanced (melanoma)
HPA (cell line):	Cell line enhanced (BJ hTERT+, SK-BR-3, U-2197)
HPA (normal tissue):	Group enriched (heart muscle, skeletal muscle)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in essentially all cells except cells in lymphoid tissues, CNS and liver.

ANTIBODY IHC RELIABILITY
Data reliability description	Pending external verification. Presumed off target binding observed and disregarded.
Reliability score	Uncertain based on 2 antibodies. HPA024770 , HPA027115
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enhanced (melanoma)

PROTEIN EXPRESSION

STAINING SUMMARY

HPA024770	HPA027115

GENE INFORMATION
Gene name	KLHL38 (HGNC Symbol)
Synonyms	C8ORFK36
Description	Kelch-like family member 38 (HGNC Symbol)
Entrez gene summary
Chromosome	8
Cytoband	q24.13
Chromosome location (bp)	123645527 - 123652950
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000175946 (version 83.38)
Entrez gene	340359
UniProt	Q2WGJ6 (UniProt - Evidence at protein level)
neXtProt	NX_Q2WGJ6
Antibodypedia	KLHL38 antibodies

PROTEIN BROWSER

KLHL38-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
KLHL38-001 ENSP00000321475 ENST00000325995	Q2WGJ6 [Direct mapping] Kelch-like protein 38 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0004842 [ubiquitin-protein transferase activity] GO:0005515 [protein binding] GO:0016567 [protein ubiquitination] GO:0031463 [Cul3-RING ubiquitin ligase complex] Show all	581 aa 65.5 kDa	No	0