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TUBB6

GENERAL INFORMATION

Gene name

 TUBB6

Gene description

 Tubulin, beta 6 class V

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 10
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in several tissue types.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Caution, targets protein from more than one gene. External characterization data supports antibody staining.

Reliability score

 Approved based on 2 antibodies.
HPA043640 , HPA046280
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and urothelial cancer (unfavourable).
Renal cancer p<0.001
Urothelial cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Testis cancer

STAINING SUMMARY
HPA043640
HPA046280

GENE INFORMATION

Gene name

 TUBB6 (HGNC Symbol)

Synonyms

 HsT1601, MGC4083

Description

 Tubulin, beta 6 class V (HGNC Symbol)

Entrez gene summary

Chromosome

 18

Cytoband

 p11.21

Chromosome location (bp)

 12307669 - 12344320

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000176014 (version 83.38)

Entrez gene

 84617

UniProt

 Q9BUF5 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9BUF5

Antibodypedia

 TUBB6 antibodies

PROTEIN BROWSER
TUBB6-001
TUBB6-005
TUBB6-006
TUBB6-007
TUBB6-008
TUBB6-009
TUBB6-012
TUBB6-013
TUBB6-014
TUBB6-015

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TUBB6-001
ENSP00000318697
ENST00000317702
Q9BUF5 [Direct mapping]
Tubulin beta-6 chain
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0003674 [molecular_function]
GO:0003924 [GTPase activity]
GO:0005200 [structural constituent of cytoskeleton]
GO:0005525 [GTP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005874 [microtubule]
GO:0006457 [protein folding]
GO:0007017 [microtubule-based process]
GO:0043234 [protein complex]
GO:0044267 [cellular protein metabolic process]
GO:0051084 ['de novo' posttranslational protein folding]
GO:0051258 [protein polymerization]
GO:0070062 [extracellular exosome]
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 446 aa
49.9 kDa 		No 0
TUBB6-005
ENSP00000466849
ENST00000591208
K7EN98 [Direct mapping]
Tubulin beta-6 chain
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005200 [structural constituent of cytoskeleton]
GO:0005525 [GTP binding]
GO:0005874 [microtubule]
GO:0007017 [microtubule-based process]
GO:0008152 [metabolic process]
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 136 aa
14.8 kDa 		No 0
TUBB6-006
ENSP00000465040
ENST00000591909
K7EJ64 [Direct mapping]
Tubulin beta-6 chain
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005200 [structural constituent of cytoskeleton]
GO:0005525 [GTP binding]
GO:0005874 [microtubule]
GO:0007017 [microtubule-based process]
GO:0008152 [metabolic process]
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 104 aa
11.7 kDa 		No 0
TUBB6-007
ENSP00000465891
ENST00000590693
K7EL29 [Direct mapping]
Tubulin beta-6 chain
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005200 [structural constituent of cytoskeleton]
GO:0005525 [GTP binding]
GO:0005874 [microtubule]
GO:0007017 [microtubule-based process]
GO:0008152 [metabolic process]
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 130 aa
14.3 kDa 		No 0
TUBB6-008
ENSP00000468777
ENST00000590103
K7ESM5 [Direct mapping]
Tubulin beta-6 chain
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005200 [structural constituent of cytoskeleton]
GO:0005525 [GTP binding]
GO:0005737 [cytoplasm]
GO:0005874 [microtubule]
GO:0007017 [microtubule-based process]
GO:0008152 [metabolic process]
GO:0043234 [protein complex]
GO:0051258 [protein polymerization]
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 338 aa
37.4 kDa 		No 0
TUBB6-009
ENSP00000468820
ENST00000586653
K7ESQ3 [Direct mapping]
Tubulin beta-6 chain
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005525 [GTP binding]
GO:0005874 [microtubule]
GO:0007017 [microtubule-based process]
GO:0008152 [metabolic process]
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 96 aa
10.7 kDa 		No 0
TUBB6-012
ENSP00000467969
ENST00000592683
K7EQT3 [Direct mapping]
Tubulin beta-6 chain
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005200 [structural constituent of cytoskeleton]
GO:0005525 [GTP binding]
GO:0005874 [microtubule]
GO:0007017 [microtubule-based process]
GO:0008152 [metabolic process]
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 104 aa
11.5 kDa 		No 0
TUBB6-013
ENSP00000465386
ENST00000590967
K7EJZ4 [Direct mapping]
Tubulin beta-6 chain
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005525 [GTP binding]
GO:0005874 [microtubule]
GO:0007017 [microtubule-based process]
GO:0008152 [metabolic process]
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 115 aa
12.5 kDa 		No 0
TUBB6-014
ENSP00000468571
ENST00000591463
K7ES63 [Direct mapping]
Tubulin beta-6 chain
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005200 [structural constituent of cytoskeleton]
GO:0005525 [GTP binding]
GO:0005874 [microtubule]
GO:0007017 [microtubule-based process]
GO:0008152 [metabolic process]
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 116 aa
12.6 kDa 		No 0
TUBB6-015
ENSP00000465448
ENST00000586691
K7EK43 [Direct mapping]
Tubulin beta-6 chain
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005525 [GTP binding]
GO:0005874 [microtubule]
GO:0007017 [microtubule-based process]
GO:0008152 [metabolic process]
Show all
 31 aa
3.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.