Expression of MBLAC2 in cancer - Summary - The Human Protein Atlas

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MBLAC2

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	MBLAC2
Gene description	Metallo-beta-lactamase domain containing 2
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA037757
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA037757

GENE INFORMATION
Gene name	MBLAC2 (HGNC Symbol)
Synonyms	DKFZp686P15118, MGC46734
Description	Metallo-beta-lactamase domain containing 2 (HGNC Symbol)
Entrez gene summary
Chromosome	5
Cytoband	q14.3
Chromosome location (bp)	90458203 - 90474768
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000176055 (version 83.38)
Entrez gene	153364
UniProt	Q68D91 (UniProt - Evidence at protein level)
neXtProt	NX_Q68D91
Antibodypedia	MBLAC2 antibodies

PROTEIN BROWSER

MBLAC2-001	MBLAC2-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MBLAC2-001 ENSP00000314776 ENST00000316610	Q68D91 [Direct mapping] Metallo-beta-lactamase domain-containing protein 2 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0003674 [molecular_function] GO:0008150 [biological_process] GO:0008152 [metabolic process] GO:0016787 [hydrolase activity] GO:0046872 [metal ion binding] GO:0070062 [extracellular exosome] Show all	279 aa 31.4 kDa	No	0
MBLAC2-003 ENSP00000425600 ENST00000514906	Q68D91 [Direct mapping] Metallo-beta-lactamase domain-containing protein 2 Show all	Predicted intracellular proteins Show all	GO:0003674 [molecular_function] GO:0008150 [biological_process] GO:0008152 [metabolic process] GO:0016787 [hydrolase activity] GO:0046872 [metal ion binding] GO:0070062 [extracellular exosome] Show all	199 aa 22.4 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.