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YES1

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GENERAL INFORMATION

Gene name

 YES1

Gene description

 YES proto-oncogene 1, Src family tyrosine kinase

Protein class

 Enzymes
FDA approved drug targets
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the plasma membrane & cytosol.

RNA cell category

 Mixed

Protein evidence

 Evidence at protein level

Main location

 Localized to the Plasma membrane (supported), Cytosol (supported)

DATA RELIABILITY

Reliability score

 Supported based on 1 antibody.
HPA026480
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the plasma membrane & cytosol.

Main location

 Plasma membrane (supported), Cytosol (supported)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA026480 A-431 Plasma membrane
Cytosol
HPA026480 U-2 OS Plasma membrane
Cytosol
HPA026480 U-251 MG Plasma membrane
Cytosol

GENE INFORMATION

Gene name

 YES1 (HGNC Symbol)

Synonyms

 c-yes, HsT441, Yes

Description

 YES proto-oncogene 1, Src family tyrosine kinase (HGNC Symbol)

Entrez gene summary

 This gene is the cellular homolog of the Yamaguchi sarcoma virus oncogene. The encoded protein has tyrosine kinase activity and belongs to the src family of proteins. This gene lies in close proximity to thymidylate synthase gene on chromosome 18, and a corresponding pseudogene has been found on chromosome 22. [provided by RefSeq, Jul 2008]

Chromosome

 18

Cytoband

 p11.32

Chromosome location (bp)

 721588 - 812546

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000176105 (version 83.38)

Entrez gene

 7525

UniProt

 P07947 (UniProt - Evidence at protein level)

neXtProt

 NX_P07947

Antibodypedia

 YES1 antibodies

PROTEIN BROWSER
YES1-002
YES1-003
YES1-006

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
YES1-002
ENSP00000462468
ENST00000584307
P07947 [Direct mapping]
Tyrosine-protein kinase Yes
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
FDA approved drug targets
   Small molecule drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0005102 [receptor binding]
GO:0005154 [epidermal growth factor receptor binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005815 [microtubule organizing center]
GO:0005829 [cytosol]
GO:0005884 [actin filament]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0006464 [cellular protein modification process]
GO:0006468 [protein phosphorylation]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007411 [axon guidance]
GO:0007596 [blood coagulation]
GO:0015758 [glucose transport]
GO:0019899 [enzyme binding]
GO:0030154 [cell differentiation]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0031295 [T cell costimulation]
GO:0036120 [cellular response to platelet-derived growth factor stimulus]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0042127 [regulation of cell proliferation]
GO:0043114 [regulation of vascular permeability]
GO:0044325 [ion channel binding]
GO:0045087 [innate immune response]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046777 [protein autophosphorylation]
GO:0048013 [ephrin receptor signaling pathway]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0050900 [leukocyte migration]
GO:0070062 [extracellular exosome]
GO:0071300 [cellular response to retinoic acid]
GO:0071375 [cellular response to peptide hormone stimulus]
GO:0071560 [cellular response to transforming growth factor beta stimulus]
Show all
 543 aa
60.8 kDa 		No 0
YES1-003
ENSP00000324740
ENST00000314574
P07947 [Direct mapping]
Tyrosine-protein kinase Yes
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005815 [microtubule organizing center]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0006464 [cellular protein modification process]
GO:0006468 [protein phosphorylation]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007411 [axon guidance]
GO:0007596 [blood coagulation]
GO:0019899 [enzyme binding]
GO:0030154 [cell differentiation]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0031295 [T cell costimulation]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0042127 [regulation of cell proliferation]
GO:0043114 [regulation of vascular permeability]
GO:0044325 [ion channel binding]
GO:0045087 [innate immune response]
GO:0048013 [ephrin receptor signaling pathway]
GO:0050900 [leukocyte migration]
GO:0070062 [extracellular exosome]
GO:0071375 [cellular response to peptide hormone stimulus]
Show all
 543 aa
60.8 kDa 		No 0
YES1-006
ENSP00000464380
ENST00000577961
J3QRU1 [Direct mapping]
Non-specific protein-tyrosine kinase
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0030154 [cell differentiation]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0042127 [regulation of cell proliferation]
GO:0045087 [innate immune response]
GO:0071375 [cellular response to peptide hormone stimulus]
Show all
 548 aa
61.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.