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GPX2

GENERAL INFORMATION

Gene name

 GPX2

Gene description

 Glutathione peroxidase 2

Protein class

 Cancer-related genes
Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Group enriched (A549, HaCaT, Hep G2, RT4, SCLC-21H)
HPA (normal tissue):Tissue enhanced (gallbladder, rectum)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in a few tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

 Supported based on 1 antibody.
HPA003545
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PROGNOSTIC SUMMARY
Prognostic marker in head and neck cancer (unfavourable).
Head and neck cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA003545

GENE INFORMATION

Gene name

 GPX2 (HGNC Symbol)

Synonyms

 GSHPX-GI

Description

 Glutathione peroxidase 2 (HGNC Symbol)

Entrez gene summary

 This gene is a member of the glutathione peroxidase family and encodes a selenium-dependent glutathione peroxidase that is one of two isoenzymes responsible for the majority of the glutathione-dependent hydrogen peroxide-reducing activity in the epithelium of the gastrointestinal tract. The protein encoded by this locus contains a selenocysteine (Sec) residue encoded by the UGA codon, which normally signals translation termination. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2012]

Chromosome

 14

Cytoband

 q23.3

Chromosome location (bp)

 64939152 - 64942905

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000176153 (version 83.38)

Entrez gene

 2877

UniProt

 P18283 (UniProt - Evidence at protein level)

neXtProt

 NX_P18283

Antibodypedia

 GPX2 antibodies

PROTEIN BROWSER
GPX2-001
GPX2-004
GPX2-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GPX2-001
ENSP00000374265
ENST00000389614
P18283 [Direct mapping]
Glutathione peroxidase 2
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Enzymes
   ENZYME proteins
   Oxidoreductases
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000302 [response to reactive oxygen species]
GO:0004602 [glutathione peroxidase activity]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006979 [response to oxidative stress]
GO:0009055 [electron carrier activity]
GO:0010467 [gene expression]
GO:0055114 [oxidation-reduction process]
GO:0070062 [extracellular exosome]
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 190 aa
22 kDa 		No 0
GPX2-004
ENSP00000451721
ENST00000557049
H0YJK8 [Direct mapping]
Glutathione peroxidase 2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0004602 [glutathione peroxidase activity]
GO:0006979 [response to oxidative stress]
GO:0055114 [oxidation-reduction process]
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 134 aa
15.5 kDa 		No 0
GPX2-201
ENSP00000478082
ENST00000612794
A0A087WTS0 [Direct mapping]
Glutathione peroxidase
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0004602 [glutathione peroxidase activity]
GO:0006979 [response to oxidative stress]
GO:0055114 [oxidation-reduction process]
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 189 aa
21.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.