Expression of CCDC57 in cancer - Summary - The Human Protein Atlas

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CCDC57

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CCDC57
Gene description	Coiled-coil domain containing 57
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Ubiquitous cytoplasmic stronger.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 4 antibodies. HPA023315 , HPA023326 , HPA023342 , HPA023344
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and pancreatic cancer (favourable).
Renal cancer p<0.001 Pancreatic cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA023315	HPA023326	HPA023342	HPA023344

GENE INFORMATION
Gene name	CCDC57 (HGNC Symbol)
Synonyms	FLJ00130, FLJ23754
Description	Coiled-coil domain containing 57 (HGNC Symbol)
Entrez gene summary
Chromosome	17
Cytoband	q25.3
Chromosome location (bp)	82101460 - 82212830
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000176155 (version 83.38)
Entrez gene	284001
UniProt	Q2TAC2 (UniProt - Evidence at protein level)
neXtProt	NX_Q2TAC2
Antibodypedia	CCDC57 antibodies

PROTEIN BROWSER

CCDC57-001	CCDC57-002	CCDC57-004	CCDC57-005	CCDC57-008	CCDC57-015	CCDC57-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CCDC57-001 ENSP00000374292 ENST00000389641	Q2TAC2 [Direct mapping] Coiled-coil domain-containing protein 57 Show all	Predicted intracellular proteins Show all	GO:0005515 [protein binding] Show all	916 aa 103.2 kDa	No	0
CCDC57-002 ENSP00000376154 ENST00000392343	Q2TAC2 [Direct mapping] Coiled-coil domain-containing protein 57 Show all	Predicted intracellular proteins Show all	GO:0005515 [protein binding] Show all	751 aa 85.5 kDa	No	0
CCDC57-004 ENSP00000376157 ENST00000392346	E9PDF5 [Direct mapping] Coiled-coil domain-containing protein 57 Show all	SCAMPI predicted membrane proteins Predicted intracellular proteins Show all		352 aa 38.2 kDa	No	0
CCDC57-005 ENSP00000408124 ENST00000419322	K7N7D6 [Direct mapping] Coiled-coil domain-containing protein 57 Show all	SCAMPI predicted membrane proteins Predicted intracellular proteins Show all		490 aa 52.5 kDa	No	0
CCDC57-008 ENSP00000376156 ENST00000392345	H7BYI8 [Direct mapping] Coiled-coil domain-containing protein 57 Show all	Predicted intracellular proteins Show all		212 aa 22.7 kDa	No	0
CCDC57-015 ENSP00000462653 ENST00000583053	J3KSU5 [Direct mapping] Coiled-coil domain-containing protein 57 Show all	Predicted intracellular proteins Show all		45 aa 4.6 kDa	No	0
CCDC57-201 ENSP00000376158 ENST00000392347	Q2TAC2 [Direct mapping] Coiled-coil domain-containing protein 57 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0005515 [protein binding] Show all	916 aa 103.2 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.