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SPHK1

GENERAL INFORMATION

Gene name

 SPHK1

Gene description

 Sphingosine kinase 1

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 8
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Mixed
GTEx:Mixed
FANTOM5:Mixed

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in several tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Pending external verification.

Reliability score

 Uncertain based on 2 antibodies.
HPA022829 , HPA028761
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Duodenum

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed

GENE INFORMATION

Gene name

 SPHK1 (HGNC Symbol)

Synonyms

 SPHK

Description

 Sphingosine kinase 1 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene catalyzes the phosphorylation of sphingosine to form sphingosine-1-phosphate (S1P), a lipid mediator with both intra- and extracellular functions. Intracellularly, S1P regulates proliferation and survival, and extracellularly, it is a ligand for cell surface G protein-coupled receptors. This protein, and its product S1P, play a key role in TNF-alpha signaling and the NF-kappa-B activation pathway important in inflammatory, antiapoptotic, and immune processes. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]

Chromosome

 17

Cytoband

 q25.1

Chromosome location (bp)

 76376584 - 76387860

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000176170 (version 83.38)

Entrez gene

 8877

UniProt

 Q9NYA1 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9NYA1

Antibodypedia

 SPHK1 antibodies

PROTEIN BROWSER
SPHK1-001
SPHK1-002
SPHK1-003
SPHK1-004
SPHK1-006
SPHK1-008
SPHK1-009
SPHK1-010

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SPHK1-001
ENSP00000313681
ENST00000323374
Q9NYA1 [Direct mapping]
Sphingosine kinase 1
Show all
Enzymes
   ENZYME proteins
   Transferases
   THUMBUP predicted membrane proteins
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0001568 [blood vessel development]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0001956 [positive regulation of neurotransmitter secretion]
GO:0003376 [sphingosine-1-phosphate signaling pathway]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006457 [protein folding]
GO:0006665 [sphingolipid metabolic process]
GO:0006670 [sphingosine metabolic process]
GO:0006954 [inflammatory response]
GO:0007165 [signal transduction]
GO:0007420 [brain development]
GO:0007565 [female pregnancy]
GO:0008021 [synaptic vesicle]
GO:0008284 [positive regulation of cell proliferation]
GO:0008481 [sphinganine kinase activity]
GO:0009267 [cellular response to starvation]
GO:0010800 [positive regulation of peptidyl-threonine phosphorylation]
GO:0010803 [regulation of tumor necrosis factor-mediated signaling pathway]
GO:0010976 [positive regulation of neuron projection development]
GO:0014070 [response to organic cyclic compound]
GO:0014075 [response to amine]
GO:0016301 [kinase activity]
GO:0017050 [D-erythro-sphingosine kinase activity]
GO:0019371 [cyclooxygenase pathway]
GO:0019722 [calcium-mediated signaling]
GO:0030148 [sphingolipid biosynthetic process]
GO:0030307 [positive regulation of cell growth]
GO:0030335 [positive regulation of cell migration]
GO:0030424 [axon]
GO:0031398 [positive regulation of protein ubiquitination]
GO:0032026 [response to magnesium ion]
GO:0032570 [response to progesterone]
GO:0032651 [regulation of interleukin-1 beta production]
GO:0033198 [response to ATP]
GO:0035556 [intracellular signal transduction]
GO:0038036 [sphingosine-1-phosphate receptor activity]
GO:0042346 [positive regulation of NF-kappaB import into nucleus]
GO:0043005 [neuron projection]
GO:0043066 [negative regulation of apoptotic process]
GO:0044267 [cellular protein metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0045766 [positive regulation of angiogenesis]
GO:0045931 [positive regulation of mitotic cell cycle]
GO:0045987 [positive regulation of smooth muscle contraction]
GO:0046512 [sphingosine biosynthetic process]
GO:0046521 [sphingoid catabolic process]
GO:0046834 [lipid phosphorylation]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048146 [positive regulation of fibroblast proliferation]
GO:0051084 ['de novo' posttranslational protein folding]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0051721 [protein phosphatase 2A binding]
GO:0070301 [cellular response to hydrogen peroxide]
GO:0070555 [response to interleukin-1]
GO:0071363 [cellular response to growth factor stimulus]
Show all
 470 aa
51.1 kDa 		No 0
SPHK1-002
ENSP00000465726
ENST00000592299
Q9NYA1 [Direct mapping]
Sphingosine kinase 1
Q53ZR5 [Target identity:100%; Query identity:100%]
Sphingosine kinase 1; Sphingosine kinase 1, isoform CRA_a; cDNA FLJ78254
Show all
Enzymes
   ENZYME proteins
   Transferases
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0003376 [sphingosine-1-phosphate signaling pathway]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006457 [protein folding]
GO:0006665 [sphingolipid metabolic process]
GO:0006670 [sphingosine metabolic process]
GO:0007165 [signal transduction]
GO:0008481 [sphinganine kinase activity]
GO:0010800 [positive regulation of peptidyl-threonine phosphorylation]
GO:0010803 [regulation of tumor necrosis factor-mediated signaling pathway]
GO:0016301 [kinase activity]
GO:0017050 [D-erythro-sphingosine kinase activity]
GO:0019722 [calcium-mediated signaling]
GO:0030148 [sphingolipid biosynthetic process]
GO:0030307 [positive regulation of cell growth]
GO:0030335 [positive regulation of cell migration]
GO:0031398 [positive regulation of protein ubiquitination]
GO:0035556 [intracellular signal transduction]
GO:0038036 [sphingosine-1-phosphate receptor activity]
GO:0042346 [positive regulation of NF-kappaB import into nucleus]
GO:0043066 [negative regulation of apoptotic process]
GO:0044267 [cellular protein metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0045766 [positive regulation of angiogenesis]
GO:0045931 [positive regulation of mitotic cell cycle]
GO:0045987 [positive regulation of smooth muscle contraction]
GO:0046512 [sphingosine biosynthetic process]
GO:0046521 [sphingoid catabolic process]
GO:0046834 [lipid phosphorylation]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048146 [positive regulation of fibroblast proliferation]
GO:0051084 ['de novo' posttranslational protein folding]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0051721 [protein phosphatase 2A binding]
Show all
 384 aa
42.5 kDa 		No 0
SPHK1-003
ENSP00000468547
ENST00000590959
Q9NYA1 [Direct mapping]
Sphingosine kinase 1
Show all
Enzymes
   ENZYME proteins
   Transferases
   THUMBUP predicted membrane proteins
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0003376 [sphingosine-1-phosphate signaling pathway]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006457 [protein folding]
GO:0006665 [sphingolipid metabolic process]
GO:0006670 [sphingosine metabolic process]
GO:0007165 [signal transduction]
GO:0008481 [sphinganine kinase activity]
GO:0010800 [positive regulation of peptidyl-threonine phosphorylation]
GO:0010803 [regulation of tumor necrosis factor-mediated signaling pathway]
GO:0016301 [kinase activity]
GO:0017050 [D-erythro-sphingosine kinase activity]
GO:0019722 [calcium-mediated signaling]
GO:0030148 [sphingolipid biosynthetic process]
GO:0030307 [positive regulation of cell growth]
GO:0030335 [positive regulation of cell migration]
GO:0031398 [positive regulation of protein ubiquitination]
GO:0035556 [intracellular signal transduction]
GO:0038036 [sphingosine-1-phosphate receptor activity]
GO:0042346 [positive regulation of NF-kappaB import into nucleus]
GO:0043066 [negative regulation of apoptotic process]
GO:0044267 [cellular protein metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0045766 [positive regulation of angiogenesis]
GO:0045931 [positive regulation of mitotic cell cycle]
GO:0045987 [positive regulation of smooth muscle contraction]
GO:0046512 [sphingosine biosynthetic process]
GO:0046521 [sphingoid catabolic process]
GO:0046834 [lipid phosphorylation]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048146 [positive regulation of fibroblast proliferation]
GO:0051084 ['de novo' posttranslational protein folding]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0051721 [protein phosphatase 2A binding]
Show all
 398 aa
43.9 kDa 		No 0
SPHK1-004
ENSP00000376285
ENST00000392496
Q9NYA1 [Direct mapping]
Sphingosine kinase 1
Q53ZR5 [Target identity:100%; Query identity:100%]
Sphingosine kinase 1; Sphingosine kinase 1, isoform CRA_a; cDNA FLJ78254
Show all
Enzymes
   ENZYME proteins
   Transferases
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0003376 [sphingosine-1-phosphate signaling pathway]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006457 [protein folding]
GO:0006665 [sphingolipid metabolic process]
GO:0006670 [sphingosine metabolic process]
GO:0007165 [signal transduction]
GO:0008481 [sphinganine kinase activity]
GO:0010800 [positive regulation of peptidyl-threonine phosphorylation]
GO:0010803 [regulation of tumor necrosis factor-mediated signaling pathway]
GO:0016301 [kinase activity]
GO:0017050 [D-erythro-sphingosine kinase activity]
GO:0019722 [calcium-mediated signaling]
GO:0030148 [sphingolipid biosynthetic process]
GO:0030307 [positive regulation of cell growth]
GO:0030335 [positive regulation of cell migration]
GO:0031398 [positive regulation of protein ubiquitination]
GO:0035556 [intracellular signal transduction]
GO:0038036 [sphingosine-1-phosphate receptor activity]
GO:0042346 [positive regulation of NF-kappaB import into nucleus]
GO:0043066 [negative regulation of apoptotic process]
GO:0044267 [cellular protein metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0045766 [positive regulation of angiogenesis]
GO:0045931 [positive regulation of mitotic cell cycle]
GO:0045987 [positive regulation of smooth muscle contraction]
GO:0046512 [sphingosine biosynthetic process]
GO:0046521 [sphingoid catabolic process]
GO:0046834 [lipid phosphorylation]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048146 [positive regulation of fibroblast proliferation]
GO:0051084 ['de novo' posttranslational protein folding]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0051721 [protein phosphatase 2A binding]
Show all
 384 aa
42.5 kDa 		No 0
SPHK1-006
ENSP00000440970
ENST00000545180
Q9NYA1 [Direct mapping]
Sphingosine kinase 1
Q53ZR5 [Target identity:100%; Query identity:100%]
Sphingosine kinase 1; Sphingosine kinase 1, isoform CRA_a; cDNA FLJ78254
Show all
Enzymes
   ENZYME proteins
   Transferases
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0003376 [sphingosine-1-phosphate signaling pathway]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006457 [protein folding]
GO:0006665 [sphingolipid metabolic process]
GO:0006670 [sphingosine metabolic process]
GO:0007165 [signal transduction]
GO:0008481 [sphinganine kinase activity]
GO:0010800 [positive regulation of peptidyl-threonine phosphorylation]
GO:0010803 [regulation of tumor necrosis factor-mediated signaling pathway]
GO:0016301 [kinase activity]
GO:0017050 [D-erythro-sphingosine kinase activity]
GO:0019722 [calcium-mediated signaling]
GO:0030148 [sphingolipid biosynthetic process]
GO:0030307 [positive regulation of cell growth]
GO:0030335 [positive regulation of cell migration]
GO:0031398 [positive regulation of protein ubiquitination]
GO:0035556 [intracellular signal transduction]
GO:0038036 [sphingosine-1-phosphate receptor activity]
GO:0042346 [positive regulation of NF-kappaB import into nucleus]
GO:0043066 [negative regulation of apoptotic process]
GO:0044267 [cellular protein metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0045766 [positive regulation of angiogenesis]
GO:0045931 [positive regulation of mitotic cell cycle]
GO:0045987 [positive regulation of smooth muscle contraction]
GO:0046512 [sphingosine biosynthetic process]
GO:0046521 [sphingoid catabolic process]
GO:0046834 [lipid phosphorylation]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048146 [positive regulation of fibroblast proliferation]
GO:0051084 ['de novo' posttranslational protein folding]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0051721 [protein phosphatase 2A binding]
Show all
 384 aa
42.5 kDa 		No 0
SPHK1-008
ENSP00000468474
ENST00000591651
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 6 aa
0.5 kDa 		No 0
SPHK1-009
ENSP00000466422
ENST00000588682
K7EMA4 [Direct mapping]
Sphingosine kinase 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
Show all
 152 aa
16.7 kDa 		No 0
SPHK1-010
ENSP00000465002
ENST00000590379
K7EJ32 [Direct mapping]
Sphingosine kinase 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
Show all
 112 aa
12.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.