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Cancer tissues showed weak to moderate cytoplasmic positivity.
GENE INFORMATION
Gene name
BNIP3 (HGNC Symbol)
Synonyms
Nip3
Description
BCL2/adenovirus E1B 19kDa interacting protein 3 (HGNC Symbol)
Entrez gene summary
This gene is encodes a mitochondrial protein that contains a BH3 domain and acts as a pro-apoptotic factor. The encoded protein interacts with anti-apoptotic proteins, including the E1B 19 kDa protein and Bcl2. This gene is silenced in tumors by DNA methylation. [provided by RefSeq, Dec 2014]