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ANAPC2

GENERAL INFORMATION

Gene name

 ANAPC2

Gene description

 Anaphase promoting complex subunit 2

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Nuclear expression in a subset of cells of several different tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
CAB018692
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PROGNOSTIC SUMMARY
Prognostic marker in pancreatic cancer (favourable), endometrial cancer (favourable), stomach cancer (favourable) and renal cancer (favourable).
Pancreatic cancer p<0.001
Endometrial cancer p<0.001
Stomach cancer p<0.001
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
CAB018692

GENE INFORMATION

Gene name

 ANAPC2 (HGNC Symbol)

Synonyms

 APC2, KIAA1406

Description

 Anaphase promoting complex subunit 2 (HGNC Symbol)

Entrez gene summary

 A large protein complex, termed the anaphase-promoting complex (APC), or the cyclosome, promotes metaphase-anaphase transition by ubiquitinating its specific substrates such as mitotic cyclins and anaphase inhibitor, which are subsequently degraded by the 26S proteasome. Biochemical studies have shown that the vertebrate APC contains eight subunits. The composition of the APC is highly conserved in organisms from yeast to humans. The product of this gene is a component of the complex and shares sequence similarity with a recently identified family of proteins called cullins, which may also be involved in ubiquitin-mediated degradation. [provided by RefSeq, Jul 2008]

Chromosome

 9

Cytoband

 q34.3

Chromosome location (bp)

 137174784 - 137188549

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000176248 (version 83.38)

Entrez gene

 29882

UniProt

 Q9UJX6 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UJX6

Antibodypedia

 ANAPC2 antibodies

PROTEIN BROWSER
ANAPC2-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ANAPC2-001
ENSP00000314004
ENST00000323927
Q9UJX6 [Direct mapping]
Anaphase-promoting complex subunit 2
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   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000278 [mitotic cell cycle]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005680 [anaphase-promoting complex]
GO:0005829 [cytosol]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0007067 [mitotic nuclear division]
GO:0007094 [mitotic spindle assembly checkpoint]
GO:0031145 [anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process]
GO:0031625 [ubiquitin protein ligase binding]
GO:0031915 [positive regulation of synaptic plasticity]
GO:0045773 [positive regulation of axon extension]
GO:0050775 [positive regulation of dendrite morphogenesis]
GO:0051301 [cell division]
GO:0051436 [negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle]
GO:0051437 [positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition]
GO:0051439 [regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle]
GO:0061630 [ubiquitin protein ligase activity]
GO:0070979 [protein K11-linked ubiquitination]
GO:0090129 [positive regulation of synapse maturation]
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 822 aa
93.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.