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COX8A

GENERAL INFORMATION

Gene name

 COX8A

Gene description

 Cytochrome c oxidase subunit VIIIA (ubiquitous)

Protein class

 Predicted membrane proteins
Transporters

Predicted localization

 Membrane

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Caution, targets protein from more than one gene.

Reliability score

 Supported based on 1 antibody.
HPA055942
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA055942

GENE INFORMATION

Gene name

 COX8A (HGNC Symbol)

Synonyms

 COX, COX8, COX8-2, COX8L, VIII, VIII-L

Description

 Cytochrome c oxidase subunit VIIIA (ubiquitous) (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is the terminal enzyme of the respiratory chain, coupling the transfer of electrons from cytochrome c to molecular oxygen, with the concomitant production of a proton electrochemical gradient across the inner mitochondrial membrane. In addition to 3 mitochondrially encoded subunits, which perform the catalytic function, the eukaryotic enzyme contains nuclear-encoded smaller subunits, ranging in number from 4 in some organisms to 10 in mammals. It has been proposed that nuclear-encoded subunits may be involved in the modulation of the catalytic function. This gene encodes one of the nuclear-encoded subunits. [provided by RefSeq, Jul 2008]

Chromosome

 11

Cytoband

 q13.1

Chromosome location (bp)

 63974607 - 63976543

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000176340 (version 83.38)

Entrez gene

 1351

UniProt

 P10176 (UniProt - Evidence at protein level)

neXtProt

 NX_P10176

Antibodypedia

 COX8A antibodies

PROTEIN BROWSER
COX8A-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
COX8A-001
ENSP00000321260
ENST00000314133
P10176 [Direct mapping]
Cytochrome c oxidase subunit 8A, mitochondrial
Q53XN1 [Target identity:100%; Query identity:100%]
COX8 protein; Cytochrome c oxidase subunit 8A (Ubiquitous); Cytochrome c oxidase subunit VIII; cDNA, FLJ92201, Homo sapiens cytochrome c oxidase subunit VIII (COX8), mRNA
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Transporters
   Primary Active Transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
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GO:0002230 [positive regulation of defense response to virus by host]
GO:0004129 [cytochrome-c oxidase activity]
GO:0005515 [protein binding]
GO:0005743 [mitochondrial inner membrane]
GO:0005751 [mitochondrial respiratory chain complex IV]
GO:0006091 [generation of precursor metabolites and energy]
GO:0006123 [mitochondrial electron transport, cytochrome c to oxygen]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0010467 [gene expression]
GO:0016021 [integral component of membrane]
GO:0022904 [respiratory electron transport chain]
GO:0044237 [cellular metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0098779 [mitophagy in response to mitochondrial depolarization]
GO:1902600 [hydrogen ion transmembrane transport]
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 69 aa
7.6 kDa 		Yes 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.