Tissue expression of TAC4 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	TAC4
Gene description	Tachykinin 4 (hemokinin)
Protein class	Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Mixed
GTEx:	Tissue enriched (pituitary gland)

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Mixed
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (pituitary gland)

GENE INFORMATION
Gene name	TAC4 (HGNC Symbol)
Synonyms	HK-1, PPT-C, Pptc
Description	Tachykinin 4 (hemokinin) (HGNC Symbol)
Entrez gene summary	This gene is a member of the tachykinin family of neurotransmitter-encoding genes. Tachykinin proteins are cleaved into small, secreted peptides that activate members of a family of receptor proteins. The products of this gene preferentially activate tachykinin receptor 1, and are thought to regulate peripheral endocrine and paracrine functions including blood pressure, the immune system, and endocrine gland secretion. The products of this gene lack a dibasic cleavage site found in other tachykinin proteins. Consequently, the nature of the cleavage products generated in vivo remains to be determined. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Chromosome	17
Cytoband	q21.33
Chromosome location (bp)	49838309 - 49848017
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000176358 (version 83.38)
Entrez gene	255061
UniProt	Q86UU9 (UniProt - Evidence at protein level)
neXtProt	NX_Q86UU9
Antibodypedia	TAC4 antibodies

PROTEIN BROWSER

TAC4-001	TAC4-003	TAC4-004	TAC4-005	TAC4-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TAC4-001 ENSP00000340461 ENST00000352793	Q86UU9 [Direct mapping] Tachykinin-4 Endokinin-A Endokinin-A/B Endokinin-C Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0005102 [receptor binding] GO:0005615 [extracellular space] GO:0005829 [cytosol] GO:0006954 [inflammatory response] GO:0007204 [positive regulation of cytosolic calcium ion concentration] GO:0007217 [tachykinin receptor signaling pathway] GO:0007267 [cell-cell signaling] GO:0008217 [regulation of blood pressure] Show all	76 aa 8 kDa	Yes	0
TAC4-003 ENSP00000334042 ENST00000334568	Q86UU9 [Direct mapping] Tachykinin-4 Endokinin-A Endokinin-A/B Endokinin-C Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0005102 [receptor binding] GO:0005615 [extracellular space] GO:0005829 [cytosol] GO:0006954 [inflammatory response] GO:0007204 [positive regulation of cytosolic calcium ion concentration] GO:0007217 [tachykinin receptor signaling pathway] GO:0007267 [cell-cell signaling] GO:0008217 [regulation of blood pressure] GO:0046878 [positive regulation of saliva secretion] Show all	113 aa 12.3 kDa	Yes	0
TAC4-004 ENSP00000381221 ENST00000398154	Q86UU9 [Direct mapping] Tachykinin-4 Endokinin-A Endokinin-A/B Endokinin-C Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0005102 [receptor binding] GO:0005615 [extracellular space] GO:0005829 [cytosol] GO:0006954 [inflammatory response] GO:0007204 [positive regulation of cytosolic calcium ion concentration] GO:0007217 [tachykinin receptor signaling pathway] GO:0007267 [cell-cell signaling] GO:0008217 [regulation of blood pressure] Show all	96 aa 10.3 kDa	Yes	0
TAC4-005 ENSP00000399702 ENST00000436235	Q86UU9 [Direct mapping] Tachykinin-4 Endokinin-A Endokinin-A/B Endokinin-C Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0005102 [receptor binding] GO:0005615 [extracellular space] GO:0005829 [cytosol] GO:0006954 [inflammatory response] GO:0007204 [positive regulation of cytosolic calcium ion concentration] GO:0007217 [tachykinin receptor signaling pathway] GO:0007267 [cell-cell signaling] GO:0008217 [regulation of blood pressure] Show all	107 aa 11.7 kDa	Yes	0
TAC4-006 ENSP00000325286 ENST00000326219	Q86UU9 [Direct mapping] Tachykinin-4 Endokinin-A Endokinin-A/B Endokinin-C Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0005102 [receptor binding] GO:0005615 [extracellular space] GO:0005829 [cytosol] GO:0006954 [inflammatory response] GO:0007204 [positive regulation of cytosolic calcium ion concentration] GO:0007217 [tachykinin receptor signaling pathway] GO:0007267 [cell-cell signaling] GO:0008217 [regulation of blood pressure] Show all	87 aa 9.4 kDa	Yes	0