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CDC26

GENERAL INFORMATION

Gene name

 CDC26

Gene description

 Cell division cycle 26

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General nuclear expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA044130
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable).
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA044130

GENE INFORMATION

Gene name

 CDC26 (HGNC Symbol)

Synonyms

 ANAPC12, APC12, C9orf17

Description

 Cell division cycle 26 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Cdc26, a component of cell cycle anaphase-promoting complex (APC). APC is composed of a group of highly conserved proteins and functions as a cell cycle-regulated ubiquitin-protein ligase. APC thus is responsible for the cell cycle regulated proteolysis of various proteins. [provided by RefSeq, Jul 2008]

Chromosome

 9

Cytoband

 q32

Chromosome location (bp)

 113255835 - 113275589

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000176386 (version 83.38)

Entrez gene

 246184

UniProt

 Q8NHZ8 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8NHZ8

Antibodypedia

 CDC26 antibodies

PROTEIN BROWSER
CDC26-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CDC26-002
ENSP00000363322
ENST00000374206
Q8NHZ8 [Direct mapping]
Anaphase-promoting complex subunit CDC26
A0A024R832 [Target identity:100%; Query identity:100%]
Cell division cycle 26, isoform CRA_a; HCG1820615
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000278 [mitotic cell cycle]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005680 [anaphase-promoting complex]
GO:0005829 [cytosol]
GO:0007067 [mitotic nuclear division]
GO:0007094 [mitotic spindle assembly checkpoint]
GO:0030071 [regulation of mitotic metaphase/anaphase transition]
GO:0031145 [anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process]
GO:0051301 [cell division]
GO:0051436 [negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle]
GO:0051437 [positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition]
GO:0051439 [regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle]
GO:0070979 [protein K11-linked ubiquitination]
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 85 aa
9.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.