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RNPEP

GENERAL INFORMATION

Gene name

 RNPEP

Gene description

 Arginyl aminopeptidase (aminopeptidase B)

Protein class

 Enzymes
Plasma proteins
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in all tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 3 antibodies.
HPA036074 , HPA036075 , HPA061487
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA036074
HPA036075
HPA061487

GENE INFORMATION

Gene name

 RNPEP

Synonyms

Description

 Arginyl aminopeptidase (aminopeptidase B) (HGNC Symbol)

Entrez gene summary

Chromosome

 1

Cytoband

 q32.1

Chromosome location (bp)

 201982372 - 202006147

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000176393 (version 83.38)

Entrez gene

 6051

UniProt

 Q9H4A4 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9H4A4

Antibodypedia

 RNPEP antibodies

PROTEIN BROWSER
RNPEP-001
RNPEP-003
RNPEP-008
RNPEP-011

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RNPEP-001
ENSP00000295640
ENST00000295640
Q9H4A4 [Direct mapping]
Aminopeptidase B
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Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Metallopeptidases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0004177 [aminopeptidase activity]
GO:0004301 [epoxide hydrolase activity]
GO:0005488 [binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005886 [plasma membrane]
GO:0006508 [proteolysis]
GO:0008235 [metalloexopeptidase activity]
GO:0008237 [metallopeptidase activity]
GO:0008270 [zinc ion binding]
GO:0019370 [leukotriene biosynthetic process]
GO:0030141 [secretory granule]
GO:0042277 [peptide binding]
GO:0043171 [peptide catabolic process]
GO:0045776 [negative regulation of blood pressure]
GO:0070006 [metalloaminopeptidase activity]
GO:0070062 [extracellular exosome]
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 650 aa
72.6 kDa 		No 0
RNPEP-003
ENSP00000356255
ENST00000367286
A6NKB8 [Direct mapping]
Aminopeptidase B
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004177 [aminopeptidase activity]
GO:0005488 [binding]
GO:0005615 [extracellular space]
GO:0006508 [proteolysis]
GO:0008237 [metallopeptidase activity]
GO:0008270 [zinc ion binding]
GO:0019370 [leukotriene biosynthetic process]
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 611 aa
68.2 kDa 		No 0
RNPEP-008
ENSP00000389602
ENST00000447312
C9JMZ3 [Direct mapping]
Aminopeptidase B
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0004177 [aminopeptidase activity]
GO:0005615 [extracellular space]
GO:0006508 [proteolysis]
GO:0008237 [metallopeptidase activity]
GO:0008270 [zinc ion binding]
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 344 aa
39 kDa 		Yes 0
RNPEP-011
ENSP00000407614
ENST00000449524
H7C2T3 [Direct mapping]
Aminopeptidase B
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004177 [aminopeptidase activity]
GO:0005615 [extracellular space]
GO:0006508 [proteolysis]
GO:0008237 [metallopeptidase activity]
GO:0008270 [zinc ion binding]
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 168 aa
19.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.