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DMRTA1

GENERAL INFORMATION

Gene name

 DMRTA1

Gene description

 DMRT-like family A1

Protein class

 Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Cell line enhanced (BJ hTERT+)
HPA (normal tissue):Tissue enhanced (parathyroid gland)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Pending external verification.

Reliability score

 Uncertain based on 1 antibody.
HPA044764
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA044764

GENE INFORMATION

Gene name

 DMRTA1

Synonyms

Description

 DMRT-like family A1 (HGNC Symbol)

Entrez gene summary

Chromosome

 9

Cytoband

 p21.3

Chromosome location (bp)

 22446841 - 22455740

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000176399 (version 83.38)

Entrez gene

 63951

UniProt

 Q5VZB9 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q5VZB9

Antibodypedia

 DMRTA1 antibodies

PROTEIN BROWSER
DMRTA1-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DMRTA1-001
ENSP00000319651
ENST00000325870
Q5VZB9 [Direct mapping]
Doublesex- and mab-3-related transcription factor A1
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Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Protein evidence (Kim et al 2014)
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GO:0000987 [core promoter proximal region sequence-specific DNA binding]
GO:0001541 [ovarian follicle development]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007548 [sex differentiation]
GO:0042803 [protein homodimerization activity]
GO:0043565 [sequence-specific DNA binding]
GO:0046872 [metal ion binding]
GO:0060179 [male mating behavior]
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 504 aa
53.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.