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RIMS2

GENERAL INFORMATION

Gene name

 RIMS2

Gene description

 Regulating synaptic membrane exocytosis 2

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 12
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (adrenal gland, cerebral cortex)
GTEx:Group enriched (adrenal gland, caudate, cerebellum, cerebral cortex, hippocampus, hypothalamus, pituitary gland)
FANTOM5:Group enriched (brain, caudate, cerebellum, hippocampus, pituitary gland, retina)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in adrenal cortex.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded. Caution, Splice and/or transcript discrepancy exists.

Reliability score

 Supported based on 1 antibody.
HPA066498
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Adrenal gland

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (adrenal gland, cerebral cortex)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (adrenal gland, caudate, cerebellum, cerebral cortex, hippocampus, hypothalamus, pituitary gland)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (brain, caudate, cerebellum, hippocampus, pituitary gland, retina)

GENE INFORMATION

Gene name

 RIMS2 (HGNC Symbol)

Synonyms

 KIAA0751, OBOE, RAB3IP3, RIM2

Description

 Regulating synaptic membrane exocytosis 2 (HGNC Symbol)

Entrez gene summary

Chromosome

 8

Cytoband

 q22.3

Chromosome location (bp)

 103500748 - 104256094

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000176406 (version 83.38)

Entrez gene

 9699

UniProt

 Q9UQ26 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UQ26

Antibodypedia

 RIMS2 antibodies

PROTEIN BROWSER
«
RIMS2-001
RIMS2-003
RIMS2-004
RIMS2-005
RIMS2-006
RIMS2-007
RIMS2-008
RIMS2-013
RIMS2-017
RIMS2-201
RIMS2-202
RIMS2-203
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RIMS2-001
ENSP00000427018
ENST00000504942
Q9UQ26 [Direct mapping]
Regulating synaptic membrane exocytosis protein 2
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0006886 [intracellular protein transport]
GO:0007269 [neurotransmitter secretion]
GO:0010628 [positive regulation of gene expression]
GO:0017137 [Rab GTPase binding]
GO:0017156 [calcium ion-dependent exocytosis]
GO:0017157 [regulation of exocytosis]
GO:0019933 [cAMP-mediated signaling]
GO:0030054 [cell junction]
GO:0030073 [insulin secretion]
GO:0042391 [regulation of membrane potential]
GO:0042734 [presynaptic membrane]
GO:0044325 [ion channel binding]
GO:0046872 [metal ion binding]
GO:0048786 [presynaptic active zone]
GO:0048791 [calcium ion-dependent exocytosis of neurotransmitter]
GO:0061669 [spontaneous neurotransmitter secretion]
GO:0070062 [extracellular exosome]
GO:0097151 [positive regulation of inhibitory postsynaptic potential]
GO:1903861 [positive regulation of dendrite extension]
GO:2000463 [positive regulation of excitatory postsynaptic potential]
Show all
 1349 aa
153.4 kDa 		No 0
RIMS2-003
ENSP00000425205
ENST00000515551
D6RDY0 [Direct mapping]
Regulating synaptic membrane exocytosis protein 2
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Predicted intracellular proteins
Show all
GO:0005515 [protein binding]
GO:0017157 [regulation of exocytosis]
GO:0048786 [presynaptic active zone]
GO:0048791 [calcium ion-dependent exocytosis of neurotransmitter]
Show all
 666 aa
77.3 kDa 		No 0
RIMS2-004
ENSP00000262231
ENST00000262231
Q9UQ26 [Direct mapping]
Regulating synaptic membrane exocytosis protein 2
Show all
Predicted intracellular proteins
Show all
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0006886 [intracellular protein transport]
GO:0010628 [positive regulation of gene expression]
GO:0017137 [Rab GTPase binding]
GO:0017156 [calcium ion-dependent exocytosis]
GO:0017157 [regulation of exocytosis]
GO:0019933 [cAMP-mediated signaling]
GO:0030054 [cell junction]
GO:0030073 [insulin secretion]
GO:0042391 [regulation of membrane potential]
GO:0042734 [presynaptic membrane]
GO:0044325 [ion channel binding]
GO:0046872 [metal ion binding]
GO:0048786 [presynaptic active zone]
GO:0048791 [calcium ion-dependent exocytosis of neurotransmitter]
GO:0061669 [spontaneous neurotransmitter secretion]
GO:0070062 [extracellular exosome]
GO:0097151 [positive regulation of inhibitory postsynaptic potential]
GO:1903861 [positive regulation of dendrite extension]
GO:2000463 [positive regulation of excitatory postsynaptic potential]
Show all
 1188 aa
135.2 kDa 		No 0
RIMS2-005
ENSP00000423559
ENST00000507740
Q9UQ26 [Direct mapping]
Regulating synaptic membrane exocytosis protein 2
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0006886 [intracellular protein transport]
GO:0010628 [positive regulation of gene expression]
GO:0017137 [Rab GTPase binding]
GO:0017156 [calcium ion-dependent exocytosis]
GO:0017157 [regulation of exocytosis]
GO:0019933 [cAMP-mediated signaling]
GO:0030054 [cell junction]
GO:0030073 [insulin secretion]
GO:0042391 [regulation of membrane potential]
GO:0042734 [presynaptic membrane]
GO:0044325 [ion channel binding]
GO:0046872 [metal ion binding]
GO:0048786 [presynaptic active zone]
GO:0048791 [calcium ion-dependent exocytosis of neurotransmitter]
GO:0061669 [spontaneous neurotransmitter secretion]
GO:0070062 [extracellular exosome]
GO:0097151 [positive regulation of inhibitory postsynaptic potential]
GO:1903861 [positive regulation of dendrite extension]
GO:2000463 [positive regulation of excitatory postsynaptic potential]
Show all
 1163 aa
132.7 kDa 		No 0
RIMS2-006
ENSP00000386228
ENST00000408894
F8W6W8 [Direct mapping]
Regulating synaptic membrane exocytosis protein 2
Show all
Predicted intracellular proteins
Show all
GO:0005515 [protein binding]
GO:0017157 [regulation of exocytosis]
GO:0048786 [presynaptic active zone]
GO:0048791 [calcium ion-dependent exocytosis of neurotransmitter]
Show all
 1253 aa
142.2 kDa 		No 0
RIMS2-007
ENSP00000390665
ENST00000436393
D6RA03 [Direct mapping]
Regulating synaptic membrane exocytosis protein 2
Show all
Predicted intracellular proteins
Show all
GO:0005515 [protein binding]
GO:0017157 [regulation of exocytosis]
GO:0048786 [presynaptic active zone]
GO:0048791 [calcium ion-dependent exocytosis of neurotransmitter]
Show all
 1367 aa
155.5 kDa 		No 0
RIMS2-008
ENSP00000488393
ENST00000507677
Predicted intracellular proteins
Show all
GO:0005515 [protein binding]
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 370 aa
41.8 kDa 		No 0
RIMS2-013
ENSP00000428478
ENST00000523362
E5RI36 [Direct mapping]
Regulating synaptic membrane exocytosis protein 2
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Predicted intracellular proteins
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GO:0005515 [protein binding]
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 258 aa
28.1 kDa 		No 0
RIMS2-017
ENSP00000487907
ENST00000632716
Predicted intracellular proteins
Show all
GO:0005515 [protein binding]
GO:0006886 [intracellular protein transport]
GO:0017137 [Rab GTPase binding]
Show all
 1121 aa
128.6 kDa 		No 0
RIMS2-201
ENSP00000342051
ENST00000339750
Q9UQ26 [Direct mapping]
Regulating synaptic membrane exocytosis protein 2
Show all
Predicted intracellular proteins
Show all
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0006886 [intracellular protein transport]
GO:0010628 [positive regulation of gene expression]
GO:0017137 [Rab GTPase binding]
GO:0017156 [calcium ion-dependent exocytosis]
GO:0017157 [regulation of exocytosis]
GO:0019933 [cAMP-mediated signaling]
GO:0030054 [cell junction]
GO:0030073 [insulin secretion]
GO:0042391 [regulation of membrane potential]
GO:0042734 [presynaptic membrane]
GO:0044325 [ion channel binding]
GO:0046872 [metal ion binding]
GO:0048786 [presynaptic active zone]
GO:0048791 [calcium ion-dependent exocytosis of neurotransmitter]
GO:0061669 [spontaneous neurotransmitter secretion]
GO:0070062 [extracellular exosome]
GO:0097151 [positive regulation of inhibitory postsynaptic potential]
GO:1903861 [positive regulation of dendrite extension]
GO:2000463 [positive regulation of excitatory postsynaptic potential]
Show all
 285 aa
31 kDa 		No 0
RIMS2-202
ENSP00000384892
ENST00000406091
A0A0A0MSC9 [Direct mapping]
Regulating synaptic membrane exocytosis protein 2
Show all
Predicted intracellular proteins
Show all
GO:0005515 [protein binding]
GO:0017157 [regulation of exocytosis]
GO:0048786 [presynaptic active zone]
GO:0048791 [calcium ion-dependent exocytosis of neurotransmitter]
Show all
 470 aa
54.2 kDa 		No 0
RIMS2-203
ENSP00000487079
ENST00000626043
A0A0D9SG19 [Direct mapping]
Regulating synaptic membrane exocytosis protein 2
Show all
Predicted intracellular proteins
Show all
GO:0005515 [protein binding]
GO:0017157 [regulation of exocytosis]
GO:0046872 [metal ion binding]
GO:0048786 [presynaptic active zone]
GO:0048791 [calcium ion-dependent exocytosis of neurotransmitter]
Show all
 1060 aa
121.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.