Expression of SYNE3 in cancer - Summary - The Human Protein Atlas

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SYNE3

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	SYNE3
Gene description	Spectrin repeat containing, nuclear envelope family member 3
Protein class	Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (Karpas-707, REH)
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Nuclear expression in several tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA055227
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA055227

GENE INFORMATION
Gene name	SYNE3 (HGNC Symbol)
Synonyms	C14orf49, FLJ25605, Nesp3, Nesprin-3, NET53
Description	Spectrin repeat containing, nuclear envelope family member 3 (HGNC Symbol)
Entrez gene summary
Chromosome	14
Cytoband	q32.13
Chromosome location (bp)	95407266 - 95475836
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000176438 (version 83.38)
Entrez gene	161176
UniProt	Q6ZMZ3 (UniProt - Evidence at protein level)
neXtProt	NX_Q6ZMZ3
Antibodypedia	SYNE3 antibodies

PROTEIN BROWSER

SYNE3-001	SYNE3-003	SYNE3-004	SYNE3-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SYNE3-001 ENSP00000450562 ENST00000557275	Q6ZMZ3 [Direct mapping] Nesprin-3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005635 [nuclear envelope] GO:0005640 [nuclear outer membrane] GO:0005791 [rough endoplasmic reticulum] GO:0007010 [cytoskeleton organization] GO:0008360 [regulation of cell shape] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0034993 [LINC complex] GO:0051015 [actin filament binding] GO:0090150 [establishment of protein localization to membrane] GO:0090286 [cytoskeletal anchoring at nuclear membrane] Show all	970 aa 111.7 kDa	No	1
SYNE3-003 ENSP00000450774 ENST00000553340	Q6ZMZ3 [Direct mapping] Nesprin-3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005635 [nuclear envelope] GO:0005640 [nuclear outer membrane] GO:0005791 [rough endoplasmic reticulum] GO:0007010 [cytoskeleton organization] GO:0008360 [regulation of cell shape] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0034993 [LINC complex] GO:0051015 [actin filament binding] GO:0090150 [establishment of protein localization to membrane] GO:0090286 [cytoskeletal anchoring at nuclear membrane] Show all	596 aa 68.6 kDa	No	0
SYNE3-004 ENSP00000452154 ENST00000554873	G3V533 [Direct mapping] Nesprin-3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0016021 [integral component of membrane] Show all	732 aa 83.9 kDa	No	1
SYNE3-005 ENSP00000334308 ENST00000334258	Q6ZMZ3 [Direct mapping] Nesprin-3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005635 [nuclear envelope] GO:0005640 [nuclear outer membrane] GO:0005791 [rough endoplasmic reticulum] GO:0007010 [cytoskeleton organization] GO:0008360 [regulation of cell shape] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0034993 [LINC complex] GO:0051015 [actin filament binding] GO:0090150 [establishment of protein localization to membrane] GO:0090286 [cytoskeletal anchoring at nuclear membrane] Show all	975 aa 112.2 kDa	No	1

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.