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CLK2

GENERAL INFORMATION

Gene name

 CLK2

Gene description

 CDC-like kinase 2

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Nuclear expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA055366
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), liver cancer (unfavourable), colorectal cancer (unfavourable) and urothelial cancer (favourable).
Renal cancer p<0.001
Liver cancer p<0.001
Colorectal cancer p<0.001
Urothelial cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA055366

GENE INFORMATION

Gene name

 CLK2 (HGNC Symbol)

Synonyms

 clk2

Description

 CDC-like kinase 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes a dual specificity protein kinase that phosphorylates serine/threonine and tyrosine-containing substrates. Activity of this protein regulates serine- and arginine-rich (SR) proteins of the spliceosomal complex, thereby influencing alternative transcript splicing. Chromosomal translocations have been characterized between this locus and the PAFAH1B3 (platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)) gene on chromosome 19, resulting in the production of a fusion protein. Note that this gene is distinct from the TELO2 gene (GeneID:9894), which shares the CLK2 alias, but encodes a protein that is involved in telomere length regulation. There is a pseudogene for this gene on chromosome 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]

Chromosome

 1

Cytoband

 q22

Chromosome location (bp)

 155262868 - 155278491

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000176444 (version 83.38)

Entrez gene

 1196

UniProt

 P49760 (UniProt - Evidence at protein level)

neXtProt

 NX_P49760

Antibodypedia

 CLK2 antibodies

PROTEIN BROWSER
CLK2-001
CLK2-002
CLK2-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CLK2-001
ENSP00000357345
ENST00000368361
P49760 [Direct mapping]
Dual specificity protein kinase CLK2
A8K7I0 [Target identity:100%; Query identity:100%]
CDC-like kinase 2, isoform CRA_a; cDNA FLJ75168, highly similar to Homo sapiens CDC-like kinase 2 (CLK2), transcript variant phclk2,mRNA
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Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CMGC Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004712 [protein serine/threonine/tyrosine kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006468 [protein phosphorylation]
GO:0010033 [response to organic substance]
GO:0010212 [response to ionizing radiation]
GO:0016607 [nuclear speck]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0032526 [response to retinoic acid]
GO:0043484 [regulation of RNA splicing]
GO:0045721 [negative regulation of gluconeogenesis]
GO:0046777 [protein autophosphorylation]
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 499 aa
60.1 kDa 		No 0
CLK2-002
ENSP00000354856
ENST00000361168
P49760 [Direct mapping]
Dual specificity protein kinase CLK2
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Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CMGC Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004712 [protein serine/threonine/tyrosine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006468 [protein phosphorylation]
GO:0010212 [response to ionizing radiation]
GO:0016607 [nuclear speck]
GO:0043484 [regulation of RNA splicing]
GO:0045721 [negative regulation of gluconeogenesis]
GO:0046777 [protein autophosphorylation]
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 498 aa
60 kDa 		No 0
CLK2-003
ENSP00000347759
ENST00000355560
B1AVT0 [Direct mapping]
Dual-specificity protein kinase CLK2
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   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006468 [protein phosphorylation]
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 497 aa
59.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.